Volume 6 Supplement 2
Diagnostic performance evaluation of post-operative serum calcitonin (CT) levels as a factor for good prognosis in medullary thyroid carcinoma (MTC)
© Gąsior-Perczak et al; licensee BioMed Central Ltd. 2013
Published: 5 April 2013
The 10-year survival rate of MTC patients is 65%. Metastases may occur even many years after the surgery. Thus, MTC patients require constant oncological monitoring. The aim of the study was to assess the post-operative levels of basal and stimulated CT, as a prognostic factor for good prognosis in MTC patients.
The study included 67 MTC patients (53 women and 14 men, aged 16-77 years) treated in our hospital (from 1996 to 2012).
Basal and stimulated CT levels were measured 3 months after the surgery. The follow-up was continued for average 7.2 years (1-16 years). In the event of increasing CT levels, imaging studies were performed to detect metastases. Correlation between the occurrence or lack of metastases and CT levels 3 months after the surgery was assessed.
Metastases to cervical lymph nodes were found in 6 patients 1 to 10 years after the surgery, one patient had metastases to ovary 11 years after the surgery, one patient had metastases to liver 5 years after the surgery and 6 cases had a constant elevation of CT levels without any findings in imaging studies. 4 patients died 1-4 years after the surgery. Post-operative CT levels in all patients mentioned above were elevated (basal CT 20-518 pg/ml; stimulated CT 199-3823 pg/ml) In the rest of the patients with normal CT level no metastases or increase in CT levels were found during the follow-up (basal CT <2.0-12 pg/ml; stimulated <2.0-19.7 pg/ml).
Normal basal and stimulated CT levels 3 months after the MTC surgery correlate very well with a good prognosis and lack of late metastases.
Further studies are required to confirm that patients with normal post-operative CT levels can be released from oncological monitoring.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.