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Fig. 1 | Thyroid Research

Fig. 1

From: Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73

Fig. 1

a Evolution of the number of viable, control or treated TT cells: 25 μM celecoxib, (cele), 100 μM GTN or a combination of celecoxib plus GTN, during 4 days. b Evolution of viable TT cell number during 4-day treatments with 100 μM indomethacin (indo), 100 μM GTN or a bi-therapy of indomethacin plus GTN. c Effects of the conjugated molecule (NO-donor conjugated to indomethacin, NCX 530), 100 μM (NO-indo100) or 200 μM NO-indomethacin (NO-indo200), during the first 4 days of treatment. Representative graphs of three (a, b) or two (c) independent experiments performed in triplicates. Adherent cells were dissociated with trypsin-EDTA and count with an hemocytometer with blue trypan exclusion. * = P < 0.05, ** = P < 0.01, *** = P < 0.001 versus control (Fisher test)

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Thyroid Research

ISSN: 1756-6614