From: Recent advances in the management of anaplastic thyroid cancer
Evaluated drug(s) | AEs grade I/II Recurrence (%) | AEs grade III/IV/V Recurrence (%) | REFERENCE(s) |
---|---|---|---|
Lenvatinib A | Fatigue, Hypertension (38–53), Decreased appetite (25–64), Nausea (13–59), Proteinuria (19–53), Mucositis/Stomatitis (25–41) | Hypertension (6–29), Decreased appetite (0–18), Thrombocytopenia (0–12), Fatigue (6) | Tahara et al. Iyer et al. |
Sorafenib A | Weight decreased (50–55), Rash/desquamation (40–55), Fatigue (30–55), Anemia (0–55), Palmar-plantar erythrodysesthesia (0–50) | Hypertension, AST increase (0–20), Rash/desquamation (0–15), Hyponatremia (0–10), Hypophosphatemia (0–10) | Savvides et al. Ito et al. |
Sunitinib B | Asthenia/fatigue (56), Mucosal AEs (53), Diarrhea (48), Cutaneous AEs (44), Hemorrhage (37) | Asthenia/fatigue (27), HFS (18), Neutropenia (17), Diarrhea (13), Mucosal AEs (11) | Ravaud et al. |
Pazopanib A | Fatigue (73), Anorexia (53), Diarrhea (47), Hypertension, Nausea (40), Protein urine positivity, Skin Hypopigmentation (33) | Hypertension, Pharyngo-laryngeal pain (13), Alanine/asprtate aminotransferase increase, Atrial fibrillation, Leukocyte/Lymphocyte count decrease, Thrombosis (7) | Bible et al. |
Gefitinib B | Rash (44), Diarrhea (37), Nausea (19), Anorexia (11) | Rash (7), Diarrhea (4) | Pennell et al. |
Vemurafenib A | Rash, Decreased appetite, Dysphagia (43), Arthralgia, Candida infection, Photosensitivity reaction, Cough, Cognitive disorder, Pruritus, Vomiting, Pyrexia, Palmar-plantar erythrodysesthesia Syndrome (29) | Fatigue (29), Rash, Pyrexia, Dehydration, Cutaneous squamous cell carcinoma (14) | Hyman et al. |
Imatinib A | Myalgia/arthralgia, Abnormal liver function test (73), Electrolyte abnormality (64), Fatigue, Anemia (55), Cough, Lymphopenia, Edema, Dyspnea (45), Nausea/Vomiting, Hyperglycemia (36) | Lymphopenia (45), Edema (27), Electrolyte abnormality, Syncope, Electrolyte abnormality, Nausea/Voimiting, Anemia (18) | Ha et al. |
Axitinib B | Fatigue, Diarrhea (45), Nausea (33), Anorexia (30), Stomatitis (25), Weight decrease (22) | Hypertension (12), Proteinuria, Fatigue (5), Headache, Weight decrease, Diarrhea (3) | Cohen et al. |
Dabrafenib + Trametinib A | Fatigue (19–38), Nausea (25–31), Vomiting (13–25), Pyrexia (6–31), Constipation (6–25) | Anemia (6–13), Hypernatriemia (0–13), Fatigue (6), Diarrhea, Hypercalcemia, Hyperglicemia (0–6) | Subbiah et al. Iyer et al. |
Everolimus B | Stomatitis/mucositis (46–69), Anorexia (26–42), Cough (0–60), Hyperglicemia (10–49), Anemia (0–57), Fatigue (0–51) | Mucositis (11–15), Hypertension (11), Diarrhea (10), Neutropenia (5), Anorexia (2–4) | Lim et al. Schneider et al. |
Spartalizumab B | Diarrhea, Pruritus (12), Fatigue, Pyrexia (7), Anemia, Asthenia, Myalgia, Rash (5) | Anemia (5), Rash (2) | Capdevila et al. |
Fosbretabulin A | Headache (51), Lymphopenia (34), Pain (other than tumor pain and headache) (32), Prolonged QTc (28), Tumor Pain (25) | Lymphopenia (11), Tumor Pain (4), Pain (other than tumor pain and headache)(1) | Mooney et al.C |
Sorafenib + Temsirolimus B | NA | Hyperglicemia (19), Fatigue (14), Anemia (11), Alanine-aminotransferase increase, Oral mucositis (8) | Sherman et al. |
Fosbretabulin + CP A | Alopecia (31), Fatigue, Hypertension (29), Nausea (24), Diarrhea (22), Anemia, Headache (20) | Neutropenia (43), Leukopenia (26), Anemia (16), Tumor pain (6 | Sosa et al. |
Efatutazone + Paclitaxel A | Edema (40), Anemia, Fatigue (33), Nausea, Weight increase, Dyspnea (27), Insomnia, Back pain, Abdominal pain, Cough (20) | Edema (13), Leukopenia, Neutrophil count decrased, Fatigue, Pneumonia, Hypovolemia (7) | Smallridge et al.D |