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Table 1 Overview of Thyroid Leimyosarcoma Cases in the Literature

From: Primary leiomyosarcoma of the thyroid with concurrent papillary thyroid cancer: a rare case report and a review of literature

Author Ref

Date

Gender

Age (years)

Presenting Complaint

Tumor Size in cm

Outcome

Treatment (Surgery, Radiotherapy, Chemotherapy)

Previous malignancy?

[5] Thompson

1997

F

64

Multiple Nodules

7.5

DWD after 5 months

Surgery

-

[5] Thompson

1997

M

45

Mass, Weight Loss

9

Alive, NLM

Surgery, Chemotherapy

-

[5] Thompson

1997

M

68

Mass, Compression Symptoms

1.9

DWD after 18 months, NLM

?

-

[5] Thompson

1997

M

83

Mass, Compression Symptoms

5.5

DWD after 3 months, NLM

Surgery

-

[6] Zou

2016

M

83

Mass, Compression Symptoms

13.5

DWD after 5 months, Recurrence

Surgery, Chemotherapy

Thyroid Carcinosarcoma, Prostate Cancer

[7] Ramakrishnan

2002

F

3

Mass

3.5

?

Surgery

-

[8] Tulbah

1999

?

PED

??

?

NLM

?

EBV LMS

[9] Kawaguchi

1990

F

72

Mass, Compression Symptoms

?

DWD

None

Uterine Fibroids

[10] Just

2008

F

83

Mass, Pain in the Arm

6.7

DWD after 2 months, LA

Palliative

Colorectal Cancer, Breast Cancer

[11] Vujosevic

2019

F

60

Mass, Compression Symptoms

2.5

Alive, LA, LM, NLM

Surgery, Radiotherapy, Chemotherapy

Uterine Endometrial Adenocarcinoma

[12] Piana

2011

F

59

Mass

?

Alive

Surgery

Uterine Myxoid Leiomyosarcoma

[13] Mansouri

2008

F

63

Mass, Weight loss, Compression Symptoms

7

DWD after 5 months, NLM

Surgery

-

[14] Sahin

2016

M

39

Weight Loss, Compression Symptoms

2.5

DWD after 3 months, NLM

Radiotherapy as Palliative

-

[14] Sahin

2016

F

72

Mass, Compression Symptoms

?

DWD after 1.5 months, LA, LM, NLM

Surgery

-

[15] Wang

2008

F

65

Mass, Weight Loss, Cough

7.5

DWD after 4 months, LA, LM

Surgery, Chemotherapy

-

[16] Adachi

1969

F

74

Mass, Compression Symptoms, Anorexia, Weight Loss

12

DWD after 1 month, LA, LM, NLM

Chemotherapy

-

[17] Mouaqit

2013

M

65

Left arm pain

9

Alive

Surgery

-

[18] Dubrava

2022

M

62

 Left neck pain, Compression Symptoms

2.5

DWD

?

-

[19] Bashir

2021

M

69

Mass, Cervical LMA

?

?

?

-

[20] Akata

1998

F

65

Painless Swellings

 < 1

?

?

-

[21] Lida

1993

F

72

Mass

2

DWD after 51 months, NLM

Surgery

-

[22] Amal

2013

F

72

Mass

5

DWD after 2 months

Surgery

-

[23] Canu

2018

M

47

Mass, Compression Symptoms

6

Alive, Recurrence

Surgery, Chemotherapy

-

[24] Conzo

2014

M

77

Mass, Compression Symptoms

4.5–6.5

DWD after 40 days

Surgery

-

[25] Kawahara

1988

M

82

Mass

5.5

DWD after 4 months, LA

Surgery

-

[26] Ozaki

1997

F

58

Mass

5

Alive

Surgery

-

[27] Chetty

1993

F

54

?

3.5

Alive

Surgery

-

[28] Kaur

2022

F

55

Mass

11.9

DWD after 2 weeks

Surgery

-

[29] Tsugawa

1999

F

90

Mass, Compression Symptoms

?

?

Surgery

-

[30] Day

2007

M

43

Mass

6

Recurrence

Surgery

-

[31] Ege

2013

M

56

Mass, Compression Symptoms

3

DWD

Surgery

-

[32] Gupta

2017

F

65

Mass, Compression Symptoms

8.3

?

Surgery

-

[33] Kushnir

2018

F

67

Compression Symptoms

1.6, 2.5

DWD, Recurrence

Surgery

-

[34] Reddy

2019

F

50

Mass

5.9

Alive, Recurrence

Surgery, Radiotherapy, Chemotherapy

-

[35] Takayama

2001

F

66

Mass

8.5

Recurrence

Surgery

-

[36] Tanboon

2013

F

64

Mass, Compression symptoms

7

DWD after 3 months, NLM

Surgery

-

[37] Wei

2019

F

74

Mass

7

DWD after 2 months

Surgery

-

[38] Ayadi

2017

F

32

Mass

5

?

Surgery, Radiotherapy, Chemotherapy

-

[39] Bertelli

2010

M

39

Mass, Compression symptoms

3.5

Alive

Surgery, Radiotherapy

-

40 Our Case

2022

F

42

Mass

4.5

Alive

Surgery

Concurrent PTC, Uterine Fibroids

  1. DWD  Dead with disease,  NLM  Non-lymph node metastasis,  LA  Locally Advanced,  LM  Lymph Node metastasis,  PED  Pediatric,  EBV  Epstein Barr Virus,  LMS  Leiomyosarcoma,  PTC  Papillary Thyroid Cancer