The clinical significance of low dose biotin supplements (<300μg/day) in the treatment of patients with hypothyroidism: crucial or overestimated?

Table 1 Demographic characteristics

	Sex (M/F)	Age, years (15–78)	BMI (Kg/m²)	Disease		Thyroxine dose (μg/day)	Biotin dose (μg/day) (range 20–300 μg)
	Sex (M/F)	Age, years (15–78)	BMI (Kg/m²)	Hashimoto N/%	Thyroidectomy N/%	Thyroxine dose (μg/day)	Biotin dose (μg/day) (range 20–300 μg)
Biotin use N = 57	7/50	49.12 ± 2.09	25.2 ± 0.57	49/85%	8/15%	66.85 ± 3.97	91.53 ± 9.25
Controls N = 31	3/28	51.17 ± 2.38	24.9 ± 0.81	26/84%	5/16%	63.33 ± 5.37
P	0.998^b	0.546^a	0.348	0.762^b		0.944

N Number of patients, M Male, F Female, BMI Body mass index, P, Mann Whitney test for unpaired data
^aUnpaired t test for normally distributed values
^bFisher's exact test; Data presented as means ± SEM

ISSN: 1756-6614