Table 1 Patient characteristics at diagnosis and at euthyroidism when stratifying into subclinical and overt hypothyroidism

Age at diagnosis (years)

46.6 ± 14.5

52.8 ± 14.4

0.086

Weight at HQRL assessment (kg)

82.1 ± 13.6

72.2 ± 12.8

0.003*

Gender (n)

 Male

6

7

 Female

30

24

0.542

Intake of LT4 (n)

 Morning

4

7

 Bedtime

32

24

0.206

Brand of LT4 (n)

 Eltroxin®

31

25

 Euthyrox®

5

6

0.547

Dose of LT4 at euthyroidism

99.2 ± 35.7

103.0 ± 38.7

0.674

Smoker at diagnosis (n)

 Never

12

10

 Smoker

6

3

 Ex-smoker

18

18

0.846

Time to euthyroidism (days)

114 ± 85

116 ± 67

0.885

LogTSH at diagnosis^a

0.91 ± 0.25

1.18 ± 0.39

0.002*

 Anti-log TSH, mU/L

8.1

15.1

Total T3 at diagnosis, nmol/L

1.70 ± 0.31

1.48 ± 0.29

0.004*

Total T4 at diagnosis, nmol/L

78.67 ± 15.3

54.9 ± 10.9

< 0.001*

T4 uptake at diagnosis

1.08 ± 0.16

1.09 ± 0.13

0.811

FT4I at diagnosis, nmol/L^a

72.7 ± 8.5

50.8 ± 9.5

0.002*

FT3I at diagnosis nmol/L

1.59 ± 0.22

1.38 ± 0.28

< 0.001*

FT4I/logTSH at diagnosis

85.2 ± 23.7

49.4 ± 20.6

< 0.001*

FT4I/FT3I ratio at diagnosis

46.5 ± 6.3

37.6 ± 8.2

< 0.001*

LogTSH at euthyroidism^a

0.28 ± 0.24

0.33 ± 0.27

0.52

 Anti-log TSH, mU/L

1.9

2.1

Total T3 at euthyroidism, nmol/L

1.61 ± 0.26

1.49 ± 0.24

0.073

Total T4 at euthyroidism, nmol/L

101.9 ± 18.2

89.6 ± 15.2

0.004*

T4 uptake at euthyroidism

1.06 ± 0.15

1.00 ± 0.07

0.060

FT4I at euthyroidism, nmol/L^a

96.7 ± 13.9

89.5 ± 15.5

0.49

FT3I at euthyroidism nmol/L

1.53 ± 0.21

1.50 ± 0.22

0.546

FT4I/FT3I ratio at euthyroidism

63.9 ± 9.65

61.1 ± 12.8

0.310

LogAnti-TPO at diagnosis

2.80 ± 0.53

2.84 ± 0.53

0.768

 Anti-log anti-TPO, kIU/L

630

691

Time from diagnosis to HRQL assessment (days)

72 ± 53

70 ± 49

0.891