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Table 3 Comparison of ThyPRO scale scores between subclinical and overt hypothyroidism and comparison of ThyPRO scale scores between group A (decrease in plasma FT3I after initiation of levothyroxine) and group B (increase or no change in plasma FT3I after initiation of levothyroxine)

From: Severity of hypothyroidism is inversely associated with impaired quality of life in patients referred to an endocrine clinic

ThyPro scale scores

Subclinical vs overt hypothyroidism

Dynamics in FT3I following treatment

Subclinical

n = 36

Overt

n = 31

Difference (Sub—overt)

[95% CI]

p-value

Group A

n = 24

Group B

n = 43

Difference A vs B

[95% CI]

p-value

Composite score

37.8 ± 19.7

36.3 ± 18.3

1.5 [-7.8 to 10.9]

0.741

42.7 ± 19.9

33.9 ± 17.8

8.7 [-1.2 to 18.5]

0.084

Goitre symptoms

18.6 ±  ± 18.5

13.7 ± 10.8

4.9 [-2.4 to 12.2]

0.186

13.9 ± 16.6

17.6 ± 14.9

-3.7 [-11.9 to 4.5]

0.155

Hypothyroid symptoms

38.7 ± 24.8

26.0 ± 21.8

12.7a [1.3 to 24.2]

.0290

32.6 ± 22.4

32.9 ± 25.3

-0.4 [-12.5 to 11.6]

0.818

Tiredness

64.1 ± 23.6

56.8 ± 23.1

7.4 [-4.1 to 18.7]

0.202

62.5 ± 24.8

59.7 ± 22.9

2.7 [-9.6 to 15.1]

0.519

Cognitive complaints

32.9 ± 24.3

29.9 ± 24.2

3.0 [-8.9 to 14.8]

0.615

34.5 ± 21.9

29.9 ± 25.3

4.5 [-7.4 to 16.3]

0.343

Anxiety

28.9 ± 22.9

30.0 ± 19.9

-1.1 [-11.5 to 9.4]

0.841

38.1 ± 24.8

24.5 ± 17.9

13.5a [3.1 to 24.0]

0.032

Depressivity

31.2 ± 19.2

34.9 ± 17.5

-3.8 [-12.7 to 5.2]

0.404

38.3 ± 21.4

29.9 ± 16.0

8.3a [0.8 to 17.5]

0.110

Emotional susceptibility

42.6 ± 24.2

43.1 ± 20.0

-0.5 [-11.3 to 10.3]

0.925

50.7 ± 22.3

38.4 ± 21.1

12.3a [1.4 to 23.5]

0.035

Impaired social life

18.9 ± 22.1

16.7 ± 20.2

2.3 [-8.0 to 12.5]

0.662

24.3 ± 24.9

14.3 ± 17.9

9.9a (0.6 to 20.5]

0.126

Impaired daily life

28.5 ± 24.9

28.2 ± 24.9

0.3 [-11.9 to 12.5]

0.957

32.0 ± 24.6

26.4 ± 24.8

5.6 [-6.9 to 18.3]

0.379

Overall quality of life

45.8 ± 32.5

40.3 ± 30.1

5.5 [-9.7 to 20.7]

0.473

48.9 ± 32.5

40.1 ± 30.4

8.8 [-7.5 to 25.1]

0.297

  1. Mean ± SD ThyPRO scale scores (0–100, higher scores indicating worse HRQL)
  2. Statistically significant difference is highlighted in bold
  3. aDifference exceeding MIC (minimal important change) according to Nordqvist et al. [28]