Severity of hypothyroidism is inversely associated with impaired quality of life in patients referred to an endocrine clinic

Table 4 Key variables included in the regression analysis for prediction of anxiety and emotional susceptibility

All variables included in the equation	Beta Coeff (Anxiety)	P	Beta Coeff (Emotional susceptibility)	P
Gender (male/female)	0.133	0.372	0.321	0.026
Age at diagnosis (years)	-0.274	0.048	-0.313	0.018
Weight at HQRL assessment (kg)	0.083	0.563	0.157	0.248
LT4 intake (morning/at bedtime)	-0.316	0.029	-0.200	0.139
Smoking	0.124	0.358	0.227	0.079
Time to euthyroidism (days)	0.156	0.259	0.260	0.049
LogAntiTPO	0.065	0.626	-0.077	0.538
FT4I at diagnosis	-0.487	0.560	-0.780	0.324
FT3I at diagnosis	0.480	0.386	0.554	0.290
FT4I/logTSH at diagnosis	0.122	0.780	0.714	0.087
FT4I/FT3i ratio at diagnosis	0.592	0.343	0.443	0.452
LogTSH at diagnosis	0.376	0.264	0.729	0.024
Brand of LT4 (Eltroxin® or Euthyrox®)	-0.301	0.031	-0.217	0.096
Time from diagnosis to HRQL assessment (days)	-0.035	0.798	-0.085	0.504
By backward stepwise regression
Age at diagnosis (years)	-0.275	0.024	-0.304	0.012

Abbreviations: HRQL health-related quality of life, LT4 levothyroxine, Anti-TPO thyroid peroxidase antibodies, TSH thyrotropin, T3 triiodothyronine, T4 thyroxine, FT3I Free T3 index, FT4I Free T4 index

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