Table 5 Most differentially expressed miRNA´s between subclinical hypothyroid (SCH1) and euthyroid (EU1) maternal blood samples
miRNA | Mean dCq (SD) EU1 | Mean dCq (SD) SCH1 | Fold change | P-value t-test / BH adj | Target gene |
|---|---|---|---|---|---|
hsa-miR-96-5p | -4.0 (0.46) | -4.9 (0.61) | -1.9 | 0.001 / 0.380 | |
hsa-miR-223-3p | 8.9 (0.19) | 9.3 (0.32) | 1.3 | 0.003 / 0.380 | |
hsa-miR-7–1-3p | -2.9 (0.63) | -2.1 (0.35) | 1.7 | 0.004 / 0.380 | |
hsa-miR-197-3p | 1.2 (0.17) | 1.5 (0.29) | 1.3 | 0.004 / 0.380 | |
hsa-miR-24–2-5p | -1.7 (0.31) | -1.3 (0.34) | 1.4 | 0.005 / 0.380 | |
hsa-miR-23a-3p | 5.9 (0.14) | 6.1(0.20) | 1.2 | 0.005 / 0.380 | |
hsa-miR-1468-5p | -6.5 (0.37) | -7.9 (0.93) | -2.6 | 0.007 / 0.450 | |
hsa-miR-345-5p | 0.03 (0.33) | 0.51 (0.42) | 1.4 | 0.007 / 0.450 | |
hsa-miR-664a-3p | -3.7 (0.38) | -3.2 (0.40) | 1.4 | 0.008 / 0.450 | |
hsa-miR-502-3p | -2.3 (0.44) | -3.0 (0.57) | -1.5 | 0.010 / 0.450 | NRF-1, SOD2-3, TFAM |
hsa-miR-486-5p | 3.5 (0.41) | 3.0 (0.43) | -1.4 | 0.010 / 0.450 | NRF-1, SOD2-3 |
hsa-miR-125a-5p | 1.1 (0.40) | 1.6 (0.52) | 1.5 | 0.013 / 0.490 | NRF-1, TFAM |
hsa-miR-223-5p | -2.3 (0.42) | -1.8 (0.55) | 1.5 | 0.013 / 0.490 | |
hsa-miR-193a-5p | -5.7 (0.70) | -4.5 (1.2) | 2.3 | 0.014 / 0.490 | NRF-1, SOD1-3, TFAM |
hsa-miR-551a | -5.1 (0.72) | -3.9 (1.2) | 2.3 | 0.015 /0.490 | No relevant |
hsa-miR-146b-5p | -1.6 (0.31) | -2.2 (0.61) | -1.5 | 0.018 / 0.540 | SOD3, TFAM |
hsa-miR-188-5p | -3.9 (0.62) | -4.6 (0.68) | -1.6 | 0.020 / 0.560 | SOD1 + 3, TFAM |
hsa-let-7d-3p | 2.1 (0.18) | 2.3 (0.21) | 1.2 | 0.021 / 0.560 | |
hsa-miR-99b-5p | -0.44 (0.45) | 0.012 (0.42) | 1.4 | 0.024 / 0.600 | |
hsa-miR-363-3p | 0.51 (0.32) | 0.15 (0.37) | -1.3 | 0.026 / 0.600 |