Table 6 Most differentially expressed miRNA´s between subclinical hypothyroid (SCH1) and euthyroid (EU1) cord blood samples
miRNA | Mean dCq (SD) EU1 | Mean dCq (SD) SCH1 | Fold change | P-value t-test / BH adj | Target gene |
|---|---|---|---|---|---|
hsa-miR-340-3p | -4.8 (0.54) | -6.6 (0.57) | -3.4 | < 0.001 / 0.015 | |
hsa-miR-331-3p | -0.90 (0.22) | -1.3 (0.30) | -1.3 | 0.002 / 0.460 | NRF-1, SOD1-3, TFAM |
hsa-miR-597-5p | -9.8 (0.34) | -8.4 (0.52) | 2.8 | 0.003 / 0.460 | |
hsa-miR-363-5p | -6.8 (0.39) | -5.6 (0.37) | 2.4 | 0.004 / 0.460 | |
hsa-miR-654-5p | -2.5 (0.82) | -3.5 (0.47) | -2.0 | 0.008 / 0.700 | NRF-1, SOD1-2, TFAM |
hsa-miR-642a-5p | -7.3 (1.3) | -5.5 (0.99) | 3.3 | 0.010 / 0.700 | |
hsa-let-7d-3p | 1.7 (0.28) | 2.1 (0.34) | 1.3 | 0.011 / 0.700 | |
hsa-miR-208a-3p | -7.1 (0.52) | -6.0 (0.33) | 2.1 | 0.012 / 0.700 | |
hsa-miR-532-3p | -1.2 (0.31) | -0.73 (0.41) | 1.3 | 0.013 / 0.700 | SOD2-3, TFAM |
hsa-let-7 g-3p | -3.0 (0.50) | -2.5 (0.38) | 1.4 | 0.016 / 0.700 | |
hsa-miR-107 | 2.8 (0.31) | 2.4 (0.24) | -1.2 | 0.016 / 0.700 | NRF-1, SOD1-3, TFAM |
hsa-miR-424-3p | -2.2 (0.72) | -1.5 (0.37) | 1.6 | 0.019 / 0.770 | |
hsa-miR-202-3p | -5.7 (0.63) | -4.7 (0.93) | 2.0 | 0.023 / 0.770 | |
hsa-let-7b-3p | -3.2 (0.61) | -2.6 (0.35) | 1.4 | 0.024 / 0.770 | |
hsa-miR-153-3p | -5.7 (0.61) | -6.8 (1.4) | -2.2 | 0.024 / 0.770 | |
hsa-miR-501-3p | -2.2 (0.68) | -1.6 (0.34) | 1.5 | 0.026 / 0.770 | NRF-1, SOD3, TFAM |
hsa-miR-345-5p | 1.4 (0.36) | 1.8 (0.45) | 1.3 | 0.028 / 0.770 | |
hsa-miR-518d-5p | -5.0 (1.1) | -6.2 (1.2) | -2.3 | 0.028 / 0.770 | NRF-1, SOD3, TFAM |
hsa-miR-99b-3p | -6.8 (1.4) | -5.4 (1.1) | 2.6 | 0.034 / 0.800 | |
hsa-miR-26b-5p | -0.92 (0.53) | -1.5 (0.74) | -1.5 | 0.037 / 0.800 |