Table 2 Coexistence of malignant struma ovarii and cervical thyroid carcinoma case reports characteristics
Number | Reported case | Age(years) | Presentation | MSO histopathology | Metastasis | CTC histopathology | Genetic profiling |
|---|---|---|---|---|---|---|---|
1 | Lim et al. [19] 2008 | 63 | Palpable mass in the neck | FVPTC | No evidence | PTC Lymph node metastases | Unknown |
2 | Janszen et al. [28] 2008 | 52 | Unexplained weight loss | FTC | No evidence | Papillary microcarcinoma | Unknown |
3 | Marti et al. [7] 2012 | 44 | Palpable adnexal mass | PTC | No evidence | PTC ETE + Central lymph node metastasis | BRAF(V600E) - |
4 | Leite et al. [29] 2013 | 78 | Pelvic pain Significant weight loss The large mass in RLQ | PTC LV invasion - | No evidence | FVPTC LV invasion – ETE - | Unknown |
5 | Leong et al. [2] 2013 | 42 | Growing left pelvic mass | PTC LV invasion- | Positive peritoneal washing | Multifocal PTC ETE + FVPTC Perithyroidal lymph node metastasis | BRAF(V600E) - K-RAS - RET-PTC - |
6 | Krishnamurthy et al. [30] 2013 | 51 | Abdominal pain and distension Abdominopelvic mass | FVPTC | No evidence | FVPTC | Unknown |
7 | Brusca et al. [31] 2015 | 30 | Abdominal pain Increased steady weight The palpable large mass in RLQ and hypogastric region | FVPTC | No evidence | Papillary microcarcinoma | Unknown |
8 | Aguilera et al. [32] 2015 | 57 | Right ovarian mass | PTC | No evidence | Papillary microcarcinoma | Unknown |
9 | Ma et al. [10] 2016 | 47 | Sudden onset RLQ pain Emesis Vaginal spotting | PTC FVPTC Tall cell variant of PTC | No evidence | Papillary microcarcinoma FVPTC | KIT mutation + |
10 | Capitao et al. [13] 2017 | 35 | Ovarian mass in a routine pelvic exam | FVPTC | No evidence | WDT-UMP ETE – LV invasion - | BRAF(V600E) - |
11 | Middlebeek et al. [11] 2017 | 55 | Incidental thyroid nodule | PTC | No evidence | FVPTC ETE - LV invasion - | BRAF(V600E) - |
12 | Boyd et al. [33] 2017 | 30 | Acute RLQ pain | PTC LV invasion - | No evidence | PTC ETE - | Unknown |
13 | Gomes-Lima et al. [8] 2018 | 62 | Accidentally Pelvic mass in CT scan | PTC | No evidence | PTC LV invasion - ETE - | HRAS Q61R + in PTC within thyroid gland NRAS Q61R + in PTC within struma ovarii |
14 | Tzelepis et al. [12] 2019 | 32 | unknown | FVPTC LV invasion + | No evidence | PTC ETE + | BRAF(V600E)- TERT promoter mutations- |
15 | Seigel et al. [3] 2019 | 55 | Weight loss Intermittent fatigue | PTC | No evidence | PTC | Unknown |
16 | Gonzalez-Cejudo et al. [34] 2021 | 57 | Incidental CT scan finding | PTC | No evidence | Papillary microcarcinoma | Unknown |
17 | Li et al. [9] 2021 | 44 | Accidental finding of pelvic mass | PTC | No evidence | PTC ETE - | Unknown |
18 | Donato et al. [14] 2021 | 35 | Accidental finding of pelvic mass | FVPTC LV invasion - | No evidence | FVPTC LV invasion - ETE – Bilateral lung metastases (micronodules) | BRAF(V600E)- |