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Fig. 4 | Thyroid Research

Fig. 4

From: Clinical characteristics and outcomes of patients with TSH-secreting pituitary adenoma and Graves’ disease - a case report and systematic review

Fig. 4

Histopathology and immunohistochemistry of the resected pituitary tissue specimen. Sections show fragments of neuroendocrine tumor in a background of abundant fibrin deposition and hyalinized small blood vessels (black arrow fibrin) (A). The tumor cells are monomorphic with round nuclei and vesicular chromatin. No necrosis or mitotic figures seen (Black arrow hyalinized blood vessel, white arrow tumor cells) (B). By immunohistochemistry, tumor cells are strongly positive for synaptophysin (C), chromogranin (D) and cytokeratin CK AE1/AE3 (E) confirming the neuroendocrine origin of the neoplasm. Meanwhile, all other hormonal markers including TSH are negative (F)

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Thyroid Research

ISSN: 1756-6614