Table 1 Clinical characteristics and outcomes of patients included in the study
Authors | Year | Age | Gender | Clinical Features | Diagnosis | Antibodies detected | Micro/macro | Final outcome |
|---|---|---|---|---|---|---|---|---|
Arai N et al. [8] | 2017 | 40 | F | Exophthalmos | Simultaneous GD and TSHomaat diagnosis of HTH | TRAB, Anti TPO AB, Anti-TG AB | Macroadenoma | Resolution after surgery |
K. Kageyama [16] | 2007 | 21 | F | Palpitations, weight loss, goiter | TSHoma first followed by GD | TRAB | Macroadenoma | Resolution after surgery |
Kamoun et al. [9] | 2014 | 36 | F | Palpitations, heat intolerance, tremors, exophthalmos, goiter | Simultaneous GD and TSHoma at diagnosis of HTH | TRAB, Anti TPO AB | Macroadenoma | Resolution after surgery |
Koriyama et al. [18] | 2004 | 31 | F | Weight loss, sweating, goiter | TSHoma first followed by GD | Thyroid stimulation AB, anti-TPO AB, anti-TG AB | Macroadenoma | On treatment for GD |
Lee et al. [19] | 2010 | 27 | M | Palpitations, goiter | GD diagnosed first followed by TSHoma development | TRAB | Macroadenoma | Not mentioned |
Lee et al. [19] | 2010 | 28 | F | Palpitations, tremors, goiter | GD diagnosed first followed by TSHoma development | TRAB | Macroadenoma | Not mentioned |
Li et al. [10] | 2018 | 55 | M | Atrial fibrillation, heat intolerance, tremors, visual field defect | Simultaneous GD and TSHoma at diagnosis of hyperthyroidism | TRAB | Macroadenoma | Post op, he still has a residual mass with normal TSH. |
Ogawa et al. [21] | 2013 | 32 | F | Palpitations, weight loss | GD diagnosed first followed by TSHoma development | TRAB | Microadenoma | Resolution after surgery |
Okuyucu et al. [22] | 2016 | 37 | F | Exophthalmos | Simultaneous GD and TSHoma at diagnosis of hyperthyroidism | TRAB | Macroadenoma | Not mentioned |
Quinn et al. [23] | 2020 | 68 | F | Asymptomatic | GD diagnosed first followed by TSHoma development | Microadenoma | Euthyroid on BB | |
Sandler [24] | 1976 | 53 | F | Acromegaly (pre-existing), exophthalmos | Simultaneous GD and TSHoma at diagnosis of hyperthyroidism | Not reported | On treatment for GD | |
Donnell et al. [20] | 1968 | 25 | M | Heat intolerance, weight loss, sweating, tremors, visual field defect | TSHoma first followed by GD | Not reported | Not mentioned | |
Kamoi et al. [17] | 1985 | 46 | F | Heat intolerance, weight loss, sweating, tremors, goiter | TSHoma first followed by GD | Anti-TG AB | Not reported | Not mentioned |
Fu et al. [15] | 2020 | 55 | F | Palpitations, heat intolerance, weight loss, sweating, tremors | Simultaneous GD and TSHoma at diagnosis of hyperthyroidism | TRAB, thyroid stimulation AB, anti-TG AB | Macroadenoma | On treatment for GD |
Diri et al. [14] | 2016 | 56 | F | Palpitations, heat intolerance, headache | Simultaneous GD and TSHoma at diagnosis of hyperthyroidism | Anti TPO AB | Macroadenoma | Not mentioned |
Present case | NA | 46 | M | Palpitations, tremors, goiter, visual field defect | Simultaneous GD and TSHoma at diagnosis of hyperthyroidism | TRAB | Macroadenoma | Maintained on octreotide |