Fig. 3

Dose–response association between baseline thyrotropin level or thyrotropin MOM and risk of subnormal or supranormal thyrotropin. Cox proportional hazard regression model was adjusted for age, body mass index, parity, education level, alcohol consumption, passive smoking, diabetes, hypertension, and iodine nutrition status. Reference values were thyrotropin 1.75 mIU/L (A, C) and thyrotropin MOM 1.00 (B, D). Black curves indicate HR estimate; shaded areas indicate 95% confidence intervals. Abbreviations: TSH, thyrotropin; MOM, multiples of the median; HR, hazard ratios. Note: The specific number of knots of each model: A: 3; B:5; C:4; D:3