Table 2 Distribution of IKBL and NFKBIA genotypes in patients with Graves' disease (GD) and in healthy controls
Gene | polymorphism | genotype | GD (%)N = 481 | Controls (%)N = 455 | p/pc value OR (95%CI) | ||
|---|---|---|---|---|---|---|---|
IKBL | promoter -62 | TT | 183 | (38.0) | 226 | (49.7) | p = 0.001* |
AT | 221 | (46.0) | 181 | (39.8) | pc = 0.018 | ||
AA | 77 | (16.0) | 48 | (10.5) | OR = 1.54 (1.20-1.99) | ||
intron 1 | CC | 186 | (38.7) | 223 | (49.0) | p = 0.001* | |
CT | 240 | (49.9) | 187 | (41.1) | pc = 0.018 | ||
TT | 55 | (11.4) | 45 | (9.9) | OR = 1.52(1.18-1.98) | ||
exon 4 | TT | 441 | (91.7) | 414 | (91.0) | NS | |
CT | 40 | (8.3) | 41 | (9.0) | |||
CC | 0 | (0.0) | 0 | (0.0) | |||
NFKBIA | 3'UTR | GG | 160 | (33.2) | 134 | (29.5) | NS |
AG | 235 | (48.9) | 234 | (51.4) | |||
AA | 86 | (17.9) | 87 | (19.1) | |||
promoter -297 | CC | 333 | (69.2) | 310 | (68.1) | NS | |
CT | 134 | (27.9) | 132 | (29.0) | |||
TT | 14 | (2.9) | 13 | (2.9) | |||
promoter -826 | CC | 318 | (66.1) | 291 | (64.0) | NS | |
CT | 147 | (30.6) | 151 | (33.2) | |||
TT | 16 | (3.3) | 13 | (2.8) | |||