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Table 3 Frequencies of IKBL haplotypes in patients with Graves' disease (GD) and in healthy controls.

From: Association of polymorphism in genes encoding κB inhibitors (IκB) with susceptibility to and phenotype of Graves' disease: a case-control study

Gene

polymorphism 1

polymorphism 2

GD

N = 481(%)

Controls

N = 455 (%)

IKBL

promoter -62 T/A

intron 1 C/T

  

haplotypes

T

C

287 (59.7)

299 (65.6)

 

A

T

167 (34.6)

112 (24.6)

 

A

C

20 (4.2)

27 (6.0)

 

T

T

7 (1.5)

17 (3.8)

  1. Haploview software was used to construct haplotypes from population genotype data and to assess possible difference in their distribution between GD vs. healthy subjects (using a nonparametric test). The distribution of IKBL haplotypes differed significantly between GD patients and healthy subjects (p < 10-4).
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Thyroid Research

ISSN: 1756-6614