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Table 5 Frequencies of NFKBIA promoter haplotypes in subgroups of patients with Graves' disease stratified by clinical activity of thyroid associated ophtalmopathy assessed according to the NOSPECS classification.

From: Association of polymorphism in genes encoding κB inhibitors (IκB) with susceptibility to and phenotype of Graves' disease: a case-control study

Gene

polymorphism 1

polymorphism 2

Ophtalmopathy

   

NOSPECS ≥ III

NOSPECS ≤ II

NFKBIA

-297 C/T

-826 C/T

N = 170 (%)

N = 289 (%)

haplotypes

C

C

126 (74.0)

238 (82.3)

 

T

T

31 (18.4)

33 (11.3)

 

T

C

8 (4.8)

11 (3.9)

 

C

T

5 (2.8)

7 (2.5)

  1. Haploview software was used to construct haplotypes from population genotype data and to assess possible difference in their distribution. The distribution of NFKBIA promoter haplotypes differed significantly between subgroups of GD subjects stratified by the presence of clinically evident ophthalmopathy (p = 0.003).
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Thyroid Research

ISSN: 1756-6614