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Table 1 Tests of thyroid function in leptin-deficient adults, before and after treatment with r-metHuLeptin.

From: Congenital leptin deficiency and thyroid function

  

Before leptin

One year after

Two years after

Four years after

Six years after

Six years after (off leptin)

Seven years after

Eight years after

TSH (mU/L)

A

3.8

*

4.5

4.17

*

*

*

*

 

B

0.93

1.1

*

0.64

1.68

1.26

0.68

1.38

 

C

1.5

*

*

*

1.09

1.61

1.27

1.0

 

D

2.4

0.88

*

0.47

0.83

1.15

1.52

1.23

Total T4

(μg/dl)

A

5.4

*

8.8

*

*

*

*

*

 

B

6.9

6.9

*

9.1

7.5

7.6

*

*

 

C

8.4

*

*

*

8.0

8.4

*

*

 

D

5.2

7.9

*

10.9

7.5

6.5

*

*

Total T3

(ng/dl)

A

*

*

*

*

*

*

*

*

 

B

114

112

167

121

121

*

*

*

 

C

118

*

*

*

112

118

*

*

 

D

76

125

*

110

122

106

*

*

Free T4

(ng/dl)

A

1.3

*

1.2

1.49

*

*

*

*

 

B

*

*

*

*

1.0

*

0.9

1.34

 

C

*

*

*

*

1.1

1.3

0.8

1.47

 

D

*

*

*

*

1.1

1.0

0.73

1.16

BMI (kg/m2)

A

39.6

24.8

23.8

22.6

*

*

*

*

 

B

51.4

24.5

22.6

23.7

23.3

26.7

25.8

25.4

 

C

46.7

26.0

26.0

25.0

26.7

29.0

30.3

32.2

 

D

55.4

35.0

28.0

31.7

33.3

36.2

32.5

36.5

  1. * Not available
  2. Reference ranges: TSH: 0.40-4.0 mU/L; total T4: 4.5-12.5 μg/dl; total T3: 75-178 ng/dl; free T4: 0.7-2.1 ng/dl
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Thyroid Research

ISSN: 1756-6614