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Table 3 Univariate analysis of potential predictive factors for scintigraphic response to 13-cis-retinoic acid therapy

From: 13-cis-retinoic acid re-differentiation therapy and recombinant human thyrotropin-aided radioiodine treatment of non-Functional metastatic thyroid cancer: a single-center, 53-patient phase 2 study

Variable

Uptake in metastases (n = 9)

No uptake in metastases (n = 44)

P¶

Potential predictive factor

   

Sex

  

Ns

Female (n = 34) vs.

7 (78%)

27 (61%)

 

Male (n = 19)

2 (22%)

17 (39%)

 

Histology

  

Ns

Papillary (n = 34) vs.

4 (44%)

30 (68%)

 

Follicular (n = 17) vs.

4 (44%)

13 (30%)

 

Insular (n = 2)

1 (2%)

1 (2%)

 

Median age

54

59

Ns

Mean time since diagnosis of metastatic disease, years

5.3

3.5

Ns

Mean time since last 131-I therapy, months

19.4

15.3

Ns

Results of the last pre-redifferentiation post therapy WBS:

  

Ns

uptake in thyroid bed

1

9

 

no uptake

8

35

 
  1. ¶ NS, not significant (P > 0.05)