Thyroid Research

Table 1 Selected auxological and hormonal data of the patients with respect to the initial diagnosis

From: Thyroid function in children with growth hormone (GH) deficiency during the initial phase of GH replacement therapy - clinical implications

	Diagnosis			p
	GHD	NSD	inactGH
n	36	23	16
Before rhGH administration
age [years]	12.0 ± 2.4	12.0 ± 2.9	12.9 ± 1.4	0.56
height SDS	-2.59 ± 0.53	-2.91 ± 0.68	-2.68 ± 0.49	0.57
TSH [mU/l]	2.42 ± 0.91	2.18 ± 1.02	2,63 ± 0.94	0.69
FT₄ [ng/dl]	1.31 ± 0.13	1.28 ± 0.17	1.29 ± 0.15	0.45
IGF-I SDS	-1.77 ± 0.92	-2.18 ± 1.23	-2.36 ± 1.06	0.58
IGF-I/IGFBP-3	0.21 ± 0.08	0.16 ± 0.05	0.16 ± 0.05	0.31
After 3-6 months of rhGH therapy
TSH [mU/l]	2.80 ± 1.28	2.60 ± 1.20	2.56 ± 1.60	0.77
FT₄ [ng/dl]	1.13 ± 0.17	1.13 ± 0.19	1.13 ± 0.13	0.73
IGF-I SDS	0.33 ± 0.99	0.40 ± 0.89	0.33 ± 0.74	0.38
IGF-I/IGFBP-3	0.38 ± 0.13	0.37 ± 0.11	0.38 ± 0.11	0.86
After 1 year of rhGH therapy
TSH [mU/l]	2.51 ± 1.23	2.15 ± 0.74	1.56 ± 0.45	0.005
FT₄ [ng/dl]	1.29 ± 0.18	1.27 ± 0.18	1.27 ± 0.13	0.72
IGF-I SDS	0.78 ± 0.88	0.62 ± 0.69	0.45 ± 0.83	0.72
IGF-I/IGFBP-3	0.43 ± 0.12	0.41 ± 0.11	0.39 ± 0.09	0.86

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