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Table 2 Selected auxological and hormonal data in euthyroid vs. previously L-T4 treated patients

From: Thyroid function in children with growth hormone (GH) deficiency during the initial phase of GH replacement therapy - clinical implications

 

euthyroid

L-T4 treated

p

n

67

8

 

Before rhGH administration

age [years]

12.3 ± 2.2

10.8 ± 3.6

0.15

height SDS

-2.65 ± 0.54

-3.13 ± 0,76

0.07

HV [cm/year]

3.6 ± 0.9

3.8 ± 1.0

0.71

TSH [mU/l]

2.42 ± 0.91

2.18 ± 1.02

0.27

FT4 [ng/dl]

1.26 ± 0.15

1.30 ± 0.15

0.97

IGF-I SDS

-2.00 ± 0.98

-2.23 ± 1.72

0.87

IGF-I/IGFBP-3

0.18 ± 0.06

0.19 ± 0.11

0.97

After 3-6 months of rhGH therapy

TSH [mU/l]

2.68 ± 1.38

2.75 ± 0.74

0.52

FT4 [ng/dl]

1.12 ± 0.13

1.17 ± 0.37

0.16

IGF-I SDS

0.49 ± 0.83

0.16 ± 1,30

0.29

IGF-I/IGFBP-3

0.39 ± 0.11

0.31 ± 0.13

0.21

After 1 year of rhGH therapy

HV [cm/year]

9.8 ± 2.1

11.7 ± 1.1

0.01

TSH [mU/l]

2.14 ± 0.90

2.94 ± 1.98

0.27

FT4 [ng/dl]

1.29 ± 0.16

1.21 ± 0.22

0.55

IGF-I SDS

0.67 ± 0.77

0.61 ± 1.31

0.72

IGF-I/IGFBP-3

0.42 ± 0.11

0.37 ± 0.15

0.64

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Thyroid Research

ISSN: 1756-6614