Thyroid Research

Table 3 Selected auxological and hormonal data of the patients according to thyroid function during rhGH administration

From: Thyroid function in children with growth hormone (GH) deficiency during the initial phase of GH replacement therapy - clinical implications

	euthyroid	hypothyroid	p
n	50	17
Before rhGH administration
age [years]	12.4 ± 2.3	12.3 ± 2.1	0.94
height SDS	-2.60 ± 0.50	-2.77 ± 0.63	0.38
HV [cm/year]	3.5 ± 1.0	3.8 ± 0.9	0.14
TSH [mU/l]	2.22 ± 0.95	2.65 ± 0.92	0.05
FT₄ [ng/dl]	1.33 ± 0.15	1.21 ± 0.11	0.01
IGF-I SDS	-2,01 ± 0.97	-1.99 ± 1.00	0.45
IGF-I/IGFBP-3	0.19 ± 0.07	0.18 ± 0.05	0.71
After 3-6 months of rhGH therapy
TSH [mU/l]	2.25 ± 0.92	3.71 ± 1.75	< 0.001
FT₄ [ng/dl]	1.16 ± 0.10	1.01 ± 0.14	< 0.001
IGF-I SDS	0.37 ± 0.81	0.54 ± 0.81	0.59
IGF-I/IGFBP-3	0.38 ± 0.11	0.42 ± 0.12	0.36
After 1 year of rhGH therapy
TSH [mU/l]	2.07 ± 0.98	2.16 ± 0.79	0.54
FT₄ [ng/dl]	1.31 ± 0.15	1.23 ± 0.14	0.11
IGF-I SDS	0.61 ± 0.67	0.83 ± 0.83	0.35
IGF-I/IGFBP-3	0.41 ± 0.09	0.45 ± 0.12	0.84
HV [cm/year]	10.0 ± 2.1	9.3 ± 2.0	0.23
ΔHV [cm/year]	6.5 ± 2.3	5.4 ± 2.1	0.01
ΔHV [%]	213 ± 118	154 ± 85	0.05

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ISSN: 1756-6614

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