Table 3 Relative expression values and the diagnostic performance of the marker genes
From: Validity of multiplex biomarker model of 6 genes for the differential diagnosis of thyroid nodules
Gene, protein name | RQ values - Mean ± SEM | Mann-Whitney U test - p-values | ROC curve - AUC (Asimptotic significance) | ||||
|---|---|---|---|---|---|---|---|
Normal | Benign | Malignant | Normal vs Malignant | Benign vs Malignant | Normal vs Malignant | Benign vs Malignant | |
LGALS3, Galectin-3 | 0.068 ± 0.013 | 0.035 ± 0.007 | 0.248 ± 0.067 | 2.2 × 10-5 | 1 × 10-8 | 0.715 (< 0.0001) | 0.832 (< 0.0001) |
TFF3, trefoil factor 3 | 0.115 ± 0.011 | 0.066 ± 0.007 | 0.037 ± 0.008 | 4.1 × 10-8 | 0.0003 | 0.782 (< 0.0001) | 0.696 (0.001) |
DPP4, Dipeptidyl peptidase-4 | 0.011 ± 0.002 | 0.0146 ± 0.003 | 0.066 ± 0.016 | 0.0001 | 0.0004 | 0.693 (< 0.0001) | 0.695 (0.001) |
MET, hepatocyte growth factor receptor | 0.048 ± 0.005 | 0.033 ± 0.004 | 0.110 ± 0.021 | 0.01 | 0.0005 | 0.610 (0.037) | 0.689 (0.001) |
CITED1, Cbp/p300-interacting transactivator 1 | 0.010 ± 0.002 | 0.021 ± 0.008 | 0.161 ± 0.048 | 0.001 | 0.001 | 0.654 (0.003) | 0.67 (0.003) |
CCND1, Cyclin D1 | 0.037 ± 0.004 | 0.036 ± 0.007 | 0.084 ± 0.017 | 0.002 | 0.001 | 0.647 (0.005) | 0.67 (0.003) |
BIRC5, Survivin | 0.025 ± 0.011 | 0.009 ± 0.002 | 0.045 ± 0.018 | 0.0001 | 0.001 | 0.694 (< 0.0001) | 0.668 (0.003) |
CDH1,E-cadherin | 0.171 ± 0.013 | 0.117 ± 0.009 | 0.158 ± 0.018 | 0.2 | 0.06 | 0.464 (0.497) | 0.525 (0.697) |