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Table 3 Relative expression values and the diagnostic performance of the marker genes

From: Validity of multiplex biomarker model of 6 genes for the differential diagnosis of thyroid nodules

Gene, protein name RQ values - Mean ± SEM Mann-Whitney U test - p-values ROC curve - AUC (Asimptotic significance)
  Normal Benign Malignant Normal vs Malignant Benign vs Malignant Normal vs Malignant Benign vs Malignant
LGALS3, Galectin-3 0.068 ± 0.013 0.035
± 0.007
0.248 ± 0.067 2.2 × 10-5 1 × 10-8 0.715
(< 0.0001)
0.832
(< 0.0001)
TFF3, trefoil factor 3 0.115
± 0.011
0.066 ± 0.007 0.037 ± 0.008 4.1 × 10-8 0.0003 0.782
(< 0.0001)
0.696
(0.001)
DPP4, Dipeptidyl peptidase-4 0.011
± 0.002
0.0146
± 0.003
0.066 ± 0.016 0.0001 0.0004 0.693
(< 0.0001)
0.695
(0.001)
MET, hepatocyte growth factor receptor 0.048
± 0.005
0.033 ± 0.004 0.110 ± 0.021 0.01 0.0005 0.610
(0.037)
0.689
(0.001)
CITED1, Cbp/p300-interacting transactivator 1 0.010
± 0.002
0.021 ± 0.008 0.161 ± 0.048 0.001 0.001 0.654
(0.003)
0.67
(0.003)
CCND1, Cyclin D1 0.037
± 0.004
0.036 ± 0.007 0.084 ± 0.017 0.002 0.001 0.647
(0.005)
0.67
(0.003)
BIRC5, Survivin 0.025
± 0.011
0.009 ± 0.002 0.045 ± 0.018 0.0001 0.001 0.694
(< 0.0001)
0.668
(0.003)
CDH1,E-cadherin 0.171
± 0.013
0.117 ± 0.009 0.158 ± 0.018 0.2 0.06 0.464
(0.497)
0.525
(0.697)