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Figure 2 | Thyroid Research

Figure 2

From: Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information

Figure 2

Homology model of human MCT8 with highlighted naturally occurring side chain substitutions. A) We highlighted wild-type amino acids of known naturally occurring mutations on the homology model of monocarboxylate transporter 8 in a conformation open to the cytosol (see figure 1). Colours were assigned according to the colour scheme in figure 1. From this three-dimensional mapping it becomes clear that none of these mutations are localized in the extra- or intracellular loops. B) The clipped surface-presentation of the MCT8 protein reveals the presumed substrate channel from the intracellular side.

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