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Figure 5 | Thyroid Research

Figure 5

From: Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information

Figure 5

Distribution of cysteines in the human MCT8 homology model. To evaluate our MCT8 model on consistency we examined already published functional data. Alanine mutants of all ten cysteines in the hMCT8 did not alter MCT8 functions such as substrate transport [16]. A) With the exception of C283 at the cytosolic channel region our “inside-open” MCT8 model suggests that none of the MCT8 cysteine side chains directly participates in the substrate channel. In conclusion the experimental data and the implications from the MCT8 model are in agreement with each other. B) The cytosolic view with clipped intracellular loops shows that most of the cysteines are localized at distance from the substrate channel. (Cavities in the model are highlighted by inner surfaces.)

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