Table 1 Tissue distribution of TH transporters from the MCT (MCT8 and MCT10), OATP (OATP1C1, OATP1A2, OATP1A4), and LAT (LAT1 and LAT2) family and of the xCT transporter and the escort protein 4F2hc.

SLC16A2

MCT8

liver, kidney, brain, heart, skeletal muscle, placenta, thyroid, testis

[14, 15, 33, 64–68]

SLC16A10

MCT10

intestine, kidney, liver, skeletal muscle, heart, placenta, pancreas

[67–69]

SLCO1C1

OATP1C1

brain, testis, cochlea

[38, 39]

SLCO1A2

OATP1A2

brain, liver, kidney, intestine

[70–72]

SLCO1A4

OATP1A4

liver, brain, testis, ovaries, retina

[23, 70, 73]

SLC7A5

LAT1

multiple (tumours, brain, spleen, placenta, testis, colon, kidney, intestine, stomach, ovary, thymus, not liver)

[74–81]

SLC7A8

LAT2

kidney, placenta, brain, intestine, testis, ovary, liver, heart, skeletal muscle, lung, stomach

[74, 79–83]

SLC7A11

xCT

brain, kidney, activated macrophages, duodenum

[20, 84, 85]

Gene

Escort protein

Localization

Reference

SLC3A2

4F2hc (CD98)

multiple (tumours, brain, intestine, kidney, liver, skeletal muscle, ovary, placenta, testis…)

[74]