Figure 2

Oxidative damage to mitochondrial DNA in porcine thyroid. mtDNA was incubated in the presence of FeSO₄ (Fe²⁺) alone [300, 150, 30, 15, 3.0, 1.5 μM]. Data are expressed as the ratio 8-oxodG/dGx10⁵. Data are from three independent experiments. Values are expressed as mean ± SE (error bars). ^ap = 0.05 vs. control (in the absence of Fe²⁺), ^bp = 0.05 vs. 300 μM, ^cp = 0.05 vs. 150 μM.