Figure 3

Oxidative damage to mitochondrial DNA in porcine thyroid. mtDNA was incubated in the presence of both substrates used together, namely in the presence of 30 μM FeSO₄ plus H₂O₂ [100, 10, 1.0, 0.5, 0.1, 0.001, 0.00001 mM]. Data are expressed as the ratio 8-oxodG/dGx10⁵. Data are from three independent experiments. Values are expressed as mean ± SE (error bars). ^ap = 0.05 vs. control (in the absence of both Fe²⁺ and H₂O₂).