Table 3 Demographic and clinical characteristics of the reported cases of hyperthyroid patients with hyperfunctioning thyroid carcinoma from the literature and the current case (n = 77)
From: A solitary hyperfunctioning thyroid nodule harboring thyroid carcinoma: review of the literature
Characteristic | |
|---|---|
Age | |
Mean—yr | 47.0 ± 19.8* |
Distribution – no. (%) | |
< 15 yr | 6 (7.9%) |
15-30 yr | 10 (13.2%) |
31-45 yr | 20 (26.3%) |
46-60 yr | 15 (19.7%) |
> 60 yr | 25 (32.9%) |
Sex – no. (%) | |
Female | 60 (77.9%) |
Male | 17 (22.1%) |
High risk features | |
Historical – no. (%) | 0 (0%) |
Ultrasonographical – no. (%) | 11 (36.7%) |
Thyroid nodule size (via ultrasound or palpation) (cm) | 4.13 ± 1.68 |
Thyroid carcinoma size on pathological review | |
Mean (cm) | 2.48 ± 1.70 |
No. (%) with size < 1cm | 8 (20.5%) |
Biochemical hyperthyroidism | |
T3 elevated – no. (%) | 39 (76.5%) |
T4 elevated – no. (%) | 27 (51.9%) |
Subclinical hyperthyroidism – no. (%) | 10 (13.0%) |
Thyrotoxic symptoms – no. (%) | 37 (78.7%) |
Compression symptoms – no. (%) | 5 (14.7%) |
Thyroid scintigraphy | |
Technetium-99m-pertechnetate – no. (%) | 16 (24.2%) |
Iodine-123 or −131 – no. (%) | 53 (80.3%) |
Fine-needle aspiration | |
Benign – no. (%) | 7 (30.4%) |
Malignant (or suspicious findings) – no. (%) | 10 (43.5%) |
Follicular neoplasm – no. (%) | 2 (8.7%) |
Nondiagnostic sample – no. (%) | 4 (17.4%) |
FNA accordant with final pathological diagnosis – no. (%) | 12 (60%) |
FNA not accordant with final pathological diagnosis – no. (%) | 9 (39.1%) |
Type of thyroid carcinoma on surgical pathological review | |
Follicular thyroid carcinoma | 28 (36.4%) |
Papillary thyroid carcinoma | 44 (57.1%) |
Follicular variant of papillary thyroid carcinoma | 8 (18.2%) |
Hurthle cell carcinoma | 6 (7.8%) |
Insular cell carcinoma | 1 (1.3%) |