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Table 5 Summarized previous reports concerning relationship between thyroid diseases and breast cancer or benign breast tumors

From: TSH receptor antibodies have predictive value for breast cancer – retrospective analysis

Parameter [Previously reported data] (n = number of patients enrolled to study)
[3] (n = 150) [18] (n = 115) [34] (n = 61) [35] (n = 175) [36] (n = 48)
BC C p BC C p BC C p BC C p BC C p
n 150 100 - 66 49 - 36 100 - 100 75 - 26 22 -
Age-yr means ± SD (min-max) 63 (38–80) age-matched - 63.5 ± 11.8 68.4 ± 12.8 ns 52.8 ± 10.2 age-matched - 63 (38–80) - - (30–85) age-matched -
TSH 3.12 ± 1.40 1.46 ± 0.82 ns 1.77 (0.15-47.9) 1.52 (0.45-14.56) ns 1.9 ± 0.7 1.8 ± 1.4 ns 4.12 ± 1.40 1.39 ± 0.79 0.030 1.36 ± 0.63 2.41 ± 0.35 <0.05
units μIU/ml mIU/dl μIU/ml μIU/ml μU/ml
FT 4 2.64 ± 0.91 1.42 ± 0.31 ns 15.70 (7.38-22.63) 15.19 (10.5-21.5) ns 9.76 ± 2.73 9.9 ± 2.4 ns 2.93 ± 0.57 1.39 ± 0.21 0.030 1.40 ± 1.64 1.10 ± 0.83 <0.05
units ng/dl pmol/dl pg/ml ng/dl ng/dl
FT 3 8.47 ± 0.75 4.48 ± 0.75 ns - 3.58 ± 0.7 3.2 ± 0.6 ns 7.25 ± 0. 75 3.42 ± 0.91 0.030 3.56 ± 3.14 2.87 ± 3.12 <0.001
units pmol/l pg/ml pmol/l pmol/ml
TgAb 140.92 ± 21.52 27.75 ± 7.60 ns 35.80 (26.1-6000.0) 27.70 (18.5-298.0) <0.001 12/36 12/100 p < 0.01 - -
units IU/ml kIU/dl Patients’ ratio with positive TgAb
TPOAb 105.82 ± 21.46 23.08 ± 4.16 0.030 6.10 (6.1-871.0) 6.10 (6.1-1621.6) ns 12/36 8/100 p < 0.01 104.57 ± 19.39- 24.81 ± 5.16 0.030 -
units IU/ml kIU/dl Patients’ ratio with positive TPOAb IU/ml
Diagnosis BC C p BC C p -
Graves’ disease - 0/66 0/49 -
AITD 57/150 17/100 0.001 16/66 8/49 -
  1. Summary of the previously reported endocrine and immunological laboratory status in patients with breast cancer (BC) and controls (C); ns, non-significant.