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Fig. 5 | Thyroid Research

Fig. 5

From: Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73

Fig. 5

Evolution of the number of viable, control or treated rMTC 6–23 cells: 200 μM indomethacin (indo), 100 μM GTN, or the combination of indomethacin plus GTN, during 6 days. Experiment performed in triplicates. Adherent cells were dissociated with trypsin-EDTA and their number was evaluated with a cell counter (blue trypan exclusion). Drug combination amplified the anti-proliferative effect of each drug (P < 0.01 versus indomethacin alone, P < 0.0001 versus GTN alone, at D6) and reduced the cell number at D6 versus D0 (P < 0.05, Fisher tests)

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