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Table 2 Clinical features of 16 patients who underwent follow-up US examinations of hypoechoic lesions that were diagnosed as possible thyroid lymphoma

From: Characteristics and natural course of hypoechoic thyroid lesions diagnosed as possible thyroid lymphomas by fine needle aspiration cytology

Case Age Sex Thyroid functiona TgAb (IU/mL) TPOAb (IU/mL) Echo pattern of hypoechoic lesions US class BethSysb Duration of follow-up (months) Before (mm) After (mm) κ/λ deviation ratioc LT4 supplementation (μg/day) TSH during follow-up Outcome
1 53 F subclinical hypothyroid (with LT4 50 μg/day) 4000 535 diffuse 3 AUSd 27 61 47 1.21 75 normal decrease
2 62 F hypothyroid 4000 600 diffuse 3.5 benigne 30 120 80 1.50 112.5 suppressed decrease
3 66 F euthyroid 28 89 nodular 3.5 AUS 12 25 11 4.61 50 normal decrease
4 69 F euthyroid 120.7 600 nodular 3 AUS 10 37 disappearance 3.14 normal disappearance
5 70 M euthyroid 54 118 nodular 3 AUS 37 15 12 1.84 normal decrease
6 71 M subclinical hypothyroid 1171 nodular 3 malignancy 6 37 23 3.20 50 normal decrease
7 72 F euthyroid 906 nodular 2.5 Suspicious for malignancy 3 27 14 2.90 50 normal decrease
8 74 F euthyroid 512.9 151 nodular 3 AUS 41 12 disappearance 2.75 normal disappearance
9 74 F euthyroid 688.8 16 nodular 3 Suspicious for malignancy 1 105 25 1.72 normal decrease
10 74 F euthyroid 121.8 nodular 3 AUS 7 16 9 2.06 75 suppressed decrease
11 77 F subclinical hypothyroid 1402 diffuse 3 AUS 25 46 40 1.53 50 normal decrease
12 83 F euthyroid 89.9 nodular 3.5 AUS 6 23 19 3.21 normal decrease
13 66 F euthyroid 235.5 nodular 4 AUS 22 22 22 0.86 75 suppressed no change
14 46 F euthyroid 609.6 nodular 3 Suspicious for malignancy 7 22 30 normal increase
15 87 M euthyroid 750.4 16 nodular 3 Suspicious for malignancy 6 19 23 4.09 normal increase
16 94 F subclinical hypothyroid 586.3 26.5 diffuse 3 Suspicious for malignancy 11 65 160 1.81 62.5 normal increase
  1. The normal range of TgAb is ≤39.9 U/mL; TPOAb: ≤27.9 U/mL. –: TPOAb not done or no levothyroxine (LT4) supplementation
  2. Intermediate US classes from class 2 to class 4 (designated as classes 2.5 and 3.5) are also used
  3. aThyroid function at the first examination and diagnosis as possible thyroid lymphoma by FNAC
  4. bThe Bethesda System for Reporting Thyroid Cytopathology
  5. cThe κ/λ deviation ratio was calculated by λ/κ ratio when the κ/λ ratio was < 1.00
  6. dAtypia of undetermined significance or follicular lesion of undetermined significance
  7. eLymphoma cannot be denied