Characteristics and natural course of hypoechoic thyroid lesions diagnosed as possible thyroid lymphomas by fine needle aspiration cytology

Table 2 Clinical features of 16 patients who underwent follow-up US examinations of hypoechoic lesions that were diagnosed as possible thyroid lymphoma

Case	Age	Sex	Thyroid function^a	TgAb (IU/mL)	TPOAb (IU/mL)	Echo pattern of hypoechoic lesions	US class	BethSys^b	Duration of follow-up (months)	Before (mm)	After (mm)	κ/λ deviation ratio^c	LT4 supplementation (μg/day)	TSH during follow-up	Outcome
1	53	F	subclinical hypothyroid (with LT4 50 μg/day)	4000≦	535	diffuse	3	AUS^d	27	61	47	1.21	75	normal	decrease
2	62	F	hypothyroid	4000≦	600≦	diffuse	3.5	benign^e	30	120	80	1.50	112.5	suppressed	decrease
3	66	F	euthyroid	28	89	nodular	3.5	AUS	12	25	11	4.61	50	normal	decrease
4	69	F	euthyroid	120.7	600≦	nodular	3	AUS	10	37	disappearance	3.14	–	normal	disappearance
5	70	M	euthyroid	54	118	nodular	3	AUS	37	15	12	1.84	–	normal	decrease
6	71	M	subclinical hypothyroid	1171	–	nodular	3	malignancy	6	37	23	3.20	50	normal	decrease
7	72	F	euthyroid	906	–	nodular	2.5	Suspicious for malignancy	3	27	14	2.90	50	normal	decrease
8	74	F	euthyroid	512.9	151	nodular	3	AUS	41	12	disappearance	2.75	–	normal	disappearance
9	74	F	euthyroid	688.8	16	nodular	3	Suspicious for malignancy	1	105	25	1.72	–	normal	decrease
10	74	F	euthyroid	121.8	–	nodular	3	AUS	7	16	9	2.06	75	suppressed	decrease
11	77	F	subclinical hypothyroid	1402	–	diffuse	3	AUS	25	46	40	1.53	50	normal	decrease
12	83	F	euthyroid	89.9	–	nodular	3.5	AUS	6	23	19	3.21	–	normal	decrease
13	66	F	euthyroid	235.5	–	nodular	4	AUS	22	22	22	0.86	75	suppressed	no change
14	46	F	euthyroid	609.6	–	nodular	3	Suspicious for malignancy	7	22	30	–	–	normal	increase
15	87	M	euthyroid	750.4	≦16	nodular	3	Suspicious for malignancy	6	19	23	4.09	–	normal	increase
16	94	F	subclinical hypothyroid	586.3	26.5	diffuse	3	Suspicious for malignancy	11	65	160	1.81	62.5	normal	increase

The normal range of TgAb is ≤39.9 U/mL; TPOAb: ≤27.9 U/mL. –: TPOAb not done or no levothyroxine (LT4) supplementation
Intermediate US classes from class 2 to class 4 (designated as classes 2.5 and 3.5) are also used
^aThyroid function at the first examination and diagnosis as possible thyroid lymphoma by FNAC
^bThe Bethesda System for Reporting Thyroid Cytopathology
^cThe κ/λ deviation ratio was calculated by λ/κ ratio when the κ/λ ratio was < 1.00
^dAtypia of undetermined significance or follicular lesion of undetermined significance
^eLymphoma cannot be denied

ISSN: 1756-6614