Effect of perchlorate and thiocyanate exposure on thyroid function of pregnant women from South-West England: a cohort study

Table 5 Studies assessing the association between urinary thiocyanate concentration and maternal thyroid status in pregnancy

Author (year)	Country	N	Gestation	Median UIC (μg/l)	Median UTC (range) (μg/l)	Association of UTC with
Author (year)	Country	N	Gestation	Median UIC (μg/l)	Median UTC (range) (μg/l)	Maternal TSH	Maternal FT4
Pearce, 2010 [6]	Italy	787^a	1st trimester	55–60	373 (132–6650)	No	Yes (negative)^c
Pearce, 2010 [6]	Wales	854^b		98–117	471 (34–3100)	No	No
Pearce, 2012 [8]	Greece	134	1st trimester	120	413 (0.6–1635)	Yes (positive)^d	No
Charatcharoenwitthaya, 2014 [9]	Thailand	200	1 s trimester	153.5	510.5 (68–3525)	Yes (positive)	Yes (negative)
Horton, 2015 [10]	USA	284	1st trimester	235 (mean)^e	1006 (mean)^e	No	No
This study	England	308	3rd trimester	88	436 (29–3290)	No	No

FT4 free T4, TSH thyroid stimulating hormone, NK not known, UIC urinary iodine concentration, UTC urinary thiocyanate concentration
^aIncludes 261 women with hypothyroidism/hypothyroxinaemia (median UIC 55 μg/l) and 526 euthyroid women (median UIC 50 μg/l)
^bIncludes 374 women with hypothyroidism/hypothyroxinaemia (median UIC 98 μg/l) and 480 euthyroid women (median UIC 117 μg/l)
^cNegative correlation in the euthyroid cohort on univariate analysis
^dPositive association on univariate analysis but no longer associated after adjustments in multivariate analysis
^eCreatinine – adjusted (μg/g creatine)

ISSN: 1756-6614