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Table 2 Severe complications of intravenous glucocorticoid therapy in patients with Graves’ orbitopathy

From: Life-threatening complications of high doses of intravenous methylprednisolone for treatment of Graves’ orbitopathy

Organ systemReportComplicationDose of methyl-prednisolone
Hepatic complicationsMarino et al. [17]Acute liver failure (7 out of 800 patients, including 3 lethal cases)3.0–24.0 g
Weissel and Hauff [18]Acute liver failure (lethal, 1 patient)15.0 g
Salvi et al. [19]Acute liver failure (1 patient)5.5 g
Cardiovascular complicationsOwecki et al. [20]Severe hypertension leading to myocardial infarction (1 patient)5.0 g
Gursoy et al. [21]Severe hypertension leading to acute hear failure without myocardial infarction (1 patient)2.0 g
Lendorf et al. [22]Myocardial infarction (1 out of 49 patients) Angina pectoris (2 out of 49 patients) Ischemic stroke (lethal, 1 out of 49 patients) Pulmonary embolism (lethal, 1 out of 49 patients)2.0–5.0 g