Antithyroid drugs and birth defects

Table 2 Observational studies on maternal thyroid function in early pregnancy and outcome of birth defects

Author	Year	Country	Sample	Exposed (n)^a	Thyroid function tests	Assays	Reference range	Association^b
Momotani et al. [10]	1984	Japan	Clinical	167	Free T4 index^c	Not specified	Not specified	Yes
Yoshihara et al. [13]	2012	Japan	Clinical	Not specified	Free T4	Lumipulse, Fuji Rebio or ECLusys, Roche Diagnostics	Trimester	No
Gianetti et al. [19]	2015	Italy	Clinical	55	Free T4, free T3 and TSH	FT4 kit and FT3 kit, Technogenetics Delfia hTSH, Pharmacia	Not specified	No
Andersen et al. [16]	2019	Denmark	Biobank	951	Free T4 and TSH	Dimension Vista, Siemens Healthineers	Pregnancy week	No
Andersen et al. [16]	2019	Denmark	Biobank	2183	Free T4 and TSH	Advia Centaur XP, Siemens Healthineers	Pregnancy week	No

^aNumber of children exposed to abnormal maternal thyroid function in the early pregnancy
^bIndicates whether an association between abnormal maternal thyroid function and birth defects was observed, see text for details
^cIn some cases the total T4, T3 and/or PBI concentration was measured

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