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Table 3 Observational studies on the use of both Methimazole and Propylthiouracil in early pregnancy and outcome of birth defects

From: Antithyroid drugs and birth defects

Author Year Country Data source Exposed (n)a Outcome in non-exposed (%) Outcome in exposed (%) Associationb
Korelitz et al. [20] 2013 United States Health insurance database 126 5.9 11.1 Yes
Andersen et al. [15] 2013 Denmark Nationwide prescription register 159 5.7 10.1 Yes
Lo et al. [21] 2015 United States Health insurance database 49 4.4 4.1 No
Andersen et al. [18] 2017 Sweden Nationwide prescription register 66 8.0 6.1 No
Seo et al. [14] 2018 Korea Health insurance database 1840 5.9 8.0 Yes
Andersen et al. [16] 2019 Denmark Nationwide prescription register 255 6.7 7.8 No
  1. aNumber of children exposed to both Methimazole and Propylthiouracil in the early pregnancy, see text for details
  2. bIndicates whether an association between exposure to both Methimazole and Propylthiouracil and birth defects was observed, see text for details