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Table 1 Epidemiology of hyperthyroidism in GTD across various settings

From: Hyperthyroidism in gestational trophoblastic disease – a literature review

Study details GTD type Total number of GTD cases reviewed in study Number of patients with hyperthyroidism
Authors Year Population and setting Biochemical (% of total GTD cases) Clinical (% of total GTD cases)
Walkington, et al. [11] 2011 Patients commencing chemotherapy for GTN at Weston Park hospital, Sheffield, United Kingdom, between January 2005 and January 2010. GTN 196 14 (7.2) 4 (2)
Sun, et al. [12] 2016 Patients with CM and PM from the Trophoblastic disease centre, United States of America, between 1994 and 2013 CM 194 31 (16) 4 (2.1)
PM 172 8 (4.7) 4 (2.3)
Norman, et al. [13] 1981 Black patients with GTD admitted to the gynaecological wards of King Edward VIII Hospital, South Africa, over a 12-month period GTN 27 15 (56) 9 (33)
Al Alaf, et al. [14] 2010 Patients with GTD admitted to Maternity Teaching Hospital, Erbil City, Iraq, from 1st October 2008 to 1st April 2009 GTN 3 10 (25) a
CM 33   
PM 4   
Bahasadri, et al. [15] 2011 Patients with CM or PM admitted to Akbarabadi Teaching Hospital, Tehran, Iran, between 21st June 1996 and 3rd July 2006 CM 230 10 (4.3) a
PM 34 0 (0) a
  1. aThere was no distinction between biochemical and clinical hypothyroidism in the study
  2. GTD Gestational trophoblastic disease
  3. GTN Gestational trophoblastic neoplasia
  4. CM Complete hydatidiform mole
  5. PM Partial hydatidiform mole