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Table 1 Characteristics of the 5 cohort studies included in qualitative and quantitative analysis

From: Malignancy risk of hyperfunctioning thyroid nodules compared with non-toxic nodules: systematic review and a meta-analysis

Authors Year Country Sample Size Mean Age Retrospective/ Prospective Diagnosis method Radiotracer Inclusion of microcarcinomas (%) Carcinoma localized to hot nodule Hot nodule – Hyperthyroida (%) Hot nodule – Euthyroida (%)
Baser, H., et al. [22] 2019 Turkey 509 54.6 Retrospective FNAB/Histology Tc99m Yes (?) No Unknown Unknown
Corrias, A., et al. [23] 2010 Italy 120 11.5 Retrospective FNAB(104) /Histology (63) Tc99m No Yes 67 33
Derosa, G., et al. [24] 1994 Italy 619 46.0 Retrospective FNAB/Histology Tc99m No No 100 0
Dirikoc, A., et al. [25] 2017 Turkey 2870 49.0 Retrospective Histology Tc99m/131I Yes (75.1%) No 100 0
Mon, S. Y., et al. [9] 2018 USA 703 48.6 Prospective FNAB Iodine Yes (9.5%) No 67 33
Slijepcevic, N., et al. [26] 2015 Serbia 2466 54.0 Retrospective Histology Unknown Yes (100%) No Unknown Unknown
Tam, A., et al. [27] 2019 Turkey 439 46.0 Retrospective FNAB/Histology Tc99m Yes (?) Yes Unknown Unknown
  1. aHyperthyroid defined as suppressed TSH, and euthyroid defined as normal TSH