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Table 2 Reported incidence of malignancy in all nodules including hot nodules and non-toxic nodules

From: Malignancy risk of hyperfunctioning thyroid nodules compared with non-toxic nodules: systematic review and a meta-analysis

Authors Overall incidence of malignancy (%) Overall proportion of hot nodules (%) Incidence of malignancy in single hot nodules (%) Incidence of malignancy in TMNG (%) Incidence of malignancy in NTN (%) Incidence of malignancy in MNG (%) FNA Biopsy results Malignant Surgical Histology
Baser, H., et al. (2019) [22] 5 73 N/A N/A 3.8 6.6 80 – Nondiagnostic
259 – Benign
17 – AUS/FLUS
2 – FN/SFN
2 – SM
4 - Malignant
8 – PTC
2 – FTC
3 – TTUMP
1 - UTC
Corrias, A., et al. (2010) [23] 30 16 11 6 22 16 3 suspicious 1 - PTC (All 3 suspicious FNAB were benign)
Derosa, G., et al. (1994) [24] 10 26 5 25 13 42 Not reported 8 - PTC
Dirikoc, A., et al. (2017) [25] 34 34 24 8 46 14 a50 – Nondiagnostic
83 – indeterminate
13 – malignant
118 PTC 7 FTC 6 Other
Mon, S. Y., et al. (2018) [9] 13 12 33 100 8 8 2 - Benign
1 - AUS/FLUS
2 FTC (Both were FNAB benign)
Slijepcevic, N., et al. (2015) [26] 16 6 7 14 16 21 Not reported 9 PTC
Tam, A., et al. (2019) [27] 25 17 N/A N/A 10 28 8 – Nondiagnostic
51 – Benign
3 – AUS/FLUS
2 – FN/SFN
1 - Malignant
10 PTC
4 FTC
(7 malignancies located outside hot nodule)
  1. TMNG toxic multinodular goiter, NTN non toxic nodule, MNG multinodular goiter, FNA fine needle aspirate, AUS/FLUS atypia of undetermined significance/follicular lesion of unknown significance, SM suspicious for malignancy, PTC papillary thyroid cancer, FTC follicular thyroid cancer, TTUMP thyroid tumour of unknown malignant potential, UTC undifferentiated thyroid cancer, Other includes Hurthle cell, medullary or undifferentiated
  2. aDenotes cytology findings in all hyperthyroid patients