Authors | Year | Study Title | Journal Title | Sample size | Age | Single or multiple toxic nodules | Type of thyroid carcinoma |
---|---|---|---|---|---|---|---|
Abs, R., et al. | 1991 | Hyperfunctioning metastatic follicular thyroid-carcinoma in Pendreds syndrome | Cancer | 1 | 66 | TMNG | FTC (metastatic) |
Alaoui, N. I. and N. Ben Rais | 2011 | Association of hyperthyroidism and well-differentiated thyroid carcinoma (medullary excluded). A propos of seven cases. | Medecine Nucleaire-Imagerie Fonctionnelle Et Metabolique | 7 | 41.4 | 4 Graves’ disease, 2 single AFTN, 1 TMNG | 5 PTC, 2 FTC |
Appetecchia, M. and M. Ducci [41] | 1998 | Hyperfunctioning differentiated thyroid carcinoma. | Journal of Endocrinological Investigation | 1 | AFTN | PTC | |
Ardito, G., et al. [42] | 1997 | Papillary thyroid carcinoma mimicking an autonomous functioning nodule. | European Journal of Surgical Oncology | 1 | AFTN | PTC | |
Bajja, M. Y., et al. [43] | 2017 | Mucinous carcinoma of the thyroid: A case report and review of the literature. | Annales D Endocrinologie | 1 | 74 | AFTN | Mucinous carcinoma of the thyroid |
Barrande, G., et al. | 1997 | Two thyroid carcinomas mimicking toxic adenomas. | Presse Medicale | 2 | 35 and 55 | AFTN | |
Becker, F. O., et al. | 1963 | The occurrence of carcinoma in “hot” thyroid nodules. Report of two cases. | Annals of Internal Medicine | 2 | |||
Bircan, R., et al. | 2007 | The second follicular thyroid carcinoma presenting as a hot thyroid nodule with a somatic 1486F TSH-Receptor (TSHR) gene mutation. | Hormone Research | 1 | FTC | ||
Bitterman, A., et al. [44] | 2006 | Thyroid carcinoma presenting as a hot nodule. | Otolaryngology - Head & Neck Surgery | 1 | 66, 57, 59 | AFTN & TMNG | PTC & 2 FTC |
Bommireddipalli, S., et al. [45] | 2010 | Follicular variant of papillary thyroid carcinoma presenting as a toxic nodule by I-123 scintigraphy. | Clinical Nuclear Medicine | 1 | 63 | AFTN | FVPTC |
Bourasseau, I., et al. | 2000 | No evidence of thyrotropin receptor and G(s alpha) gene mutation in high iodine uptake thyroid carcinoma. | Thyroid | 4 | Mean age 41.1 | 3 AFTN, 1 TMNG | 2 PTC and 2 FTC |
Calimon, M. A. P. and S. W. Lim-Uy [46] | 2014 | Papillary Thyroid Carcinoma in an Autonomous Hyperfunctioning Thyroid Nodule. | Endocrine Reviews | 1 | AFTN | PTC | |
Camacho, P., et al. [47] | 2000 | A Phe 486 thyrotropin receptor mutation in an autonomously functioning follicular carcinoma that was causing hyperthyroidism. | Thyroid | 1 | 49 | AFTN | FTC |
Campenni, A., et al. [32] | 2011 | Follicular variant of papillary thyroid carcinoma presenting as a toxic nodule in an adolescent girl | European Journal of Nuclear Medicine and Molecular Imaging | 1 | 15 | AFTN | PTC |
Castelli, V., et al. | 1994 | Occurrence of papillary carcinoma in a hyperfunctioning thyroid nodule: report of a case and diagnostic considerations | Thyroidology | 1 | PTC | ||
Cirillo, R. L., Jr., et al. [48] | 1998 | Metastatic pure papillary thyroid carcinoma presenting as a toxic hot nodule. | Clinical Nuclear Medicine | 1 | AFTN | PTC (metastatic) | |
Clement, K., et al. [49] | 1991 | Thyroid cancer revealed by an extinctive hot nodule | Presse Medicale | 1 | 62 | ||
Damle, N., et al. [33] | 2011 | Papillary carcinoma masquerading as clinically toxic adenoma in very young children. | Journal of Pediatric Endocrinology & Metabolism | 2 | 6 months and 5y | AFTN | PTC |
De Rosa, G., et al. [50] | 1990 | Thyroid carcinoma mimicking a toxic adenoma. | European Journal of Nuclear Medicine | AFTN | |||
Ducci, M., et al. [34] | 1996 | Differentiated carcinoma in autonomously functioning thyroid nodule: case report. | Acta otorhinolaryngologica Italica: organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale | 1 | 13 | AFTN | PTC |
Einert, A., et al. [51] | 1995 | A combination of unifocal thyroid autonomy and follicular carcinoma - A case report | Radiologe | 1 | 53 | AFTN | FTC |
Emmrich, P., et al. [52] | 2001 | Unifocal autonomous thyroid nodule and carcinoma. | Zentralblatt Fur Chirurgie | 2 | AFTN | FTC and PTC | |
Foppiani, L., et al. [53] | 2005 | Heterogeneous malignancy in toxic thyroid nodules | Journal of Endocrinological Investigation | 3 | 68, 38, & 62 | 2 AFTN, 1 TMNG | 3 FTC |
Fuhrer, D., et al. [54] | 2003 | Two somatic TSH receptor mutations in a patient with toxic metastasising follicular thyroid carcinoma and non-functional lung metastases. | Endocrine-Related Cancer | 1 | 59 | TMNG | FTC |
Fujimoto, Y., et al. | 1972 | Occurrence of papillary carcinoma in hyperfunctioning thyroid nodule. Report of a case. | Endocrinologia Japonica | 1 | |||
Fukata, S., et al. [55] | 1987 | Thyroid carcinoma and hot nodule | European Journal of Nuclear Medicine | 1 | 70 | AFTN | PTC |
Gardner, D. and S. C. Ho | 2014 | A rare cause of hyperthyroidism: functioning thyroid metastases | BMJ Case Reports | 1 | 66 | TMNG | FVPTC |
Gozu, H. et al. [67] | 2004 | Does a Leu 512 Arg thyrotropin receptor mutation cause an autonomously functioning papillary carcinoma? | Thyroid | 1 | ? | TMNG | PTC |
Kim, T. S., et al. | 2007 | A rare case of hyperfunctioning papillary carcinoma of the thyroid gland | Acta Oto-Laryngologica | 1 | 32 | AFTN | FVPTC |
Kuan, Y. C. and F. H. Tan | 2014 | Thyroid papillary carcinoma in a ‘hot’ thyroid nodule. | Qjm | 1 | 60 | AFTN | FVPTC |
Lado-Abeal J. et al [68] | 2010 | Identification of a paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPAR gamma) rearrangement mosaicism in a patient with an autonomous functioning follicular thyroid carcinoma bearing an activating mutation in the TSH receptor | Endocrine-Related Cancer | 1 | 55 | TMNG | FTC |
Lima, M. J., et al. | 2018 | Autonomously hyperfunctioning cystic nodule harbouring thyroid carcinoma - Case report and literature review.” | International Journal of Surgery Case Reports | 1 | 49 | AFTN | FVPTC |
Majima, T., et al. [56] | 2005 | Papillary thyroid carcinoma without metastases manifesting as an autonomously functioning thyroid nodule. | Endocrine Journal | 1 | 59 | AFTN | PTC |
Marcelino, M., et al. [28] | 2014 | Anaplastic carcinoma and toxic multinodular goiter: an unusual presentation | European Thyroid Journal | 1 | 70 | TMNG | Anaplastic thyroid carcinoma |
Mircescu, H., et al. [35] | 2000 | Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: pathologic and molecular studies. | Journal of Pediatrics | 1 | 11 | AFTN | PTC |
Mirfakhraee, S., et al. [8] | 2013 | A solitary hyperfunctioning thyroid nodule harboring thyroid carcinoma: review of the literature | Thyroid research | 1 | 29 | AFTN | FTC |
Nagai, G. R., et al. | 1987 | Scintigraphic hot nodules and thyroid carcinoma | Clinical Nuclear Medicine | 3 | 2 FTC and 1 PTC | ||
Nemec, J., et al. [57] | 1980 | Metastatic thyroid cancer with severe hyperthyroidism mimicking independent hyperfunctioning thyroid adenoma, showing transition to water-clear-tumour. | Endokrinologie | 1 | AFTN | FTC (metastatic) | |
Niepomniszcze, H., et al. [58] | 2006 | Follicular carcinoma presenting as autonomous functioning thyroid nodule and containing an activating mutation of the TSH receptor (T620I) and a mutation of the Ki-RAS (G12C) genes. | Thyroid | 1 | 64 | AFTN | FTC |
Nishida, A. T., et al. [59] | 2008 | Multifocal hyperfunctioning thyroid carcinoma without metastases. | Auris, Nasus, Larynx | 1 | 62 | TMNG | PTC |
Polyzos, S. A. and D. G. Goulis [30] | 2011 | Coincidental thyroid papillary microcarcinoma in a patient treated for a toxic adenoma of the thyroid. | Archives of Iranian Medicine | 1 | AFTN | PTC (microcarcinoma) | |
Rees, D. O., et al. [36] | 2015 | Follicular variant of papillary thyroid carcinoma: an unusual cause of thyrotoxicosis. | BMJ Case Reports | 1 | 16 | AFTN | FVPTC |
Rivas, I., et al. [29] | 1995 | Medullary thyroid carcinoma mimicking an autonomous functioning nodule | Journal of Endocrinological Investigation | 1 | 42 | AFTN | MTC |
Rubenfeld, S. and T. M. Wheeler | 1988 | Thyroid cancer presenting as a hot thyroid nodule: report of a case and review of the literature | Thyroidology | 1 | AFTN | ||
Ruggeri, R. M., et al. [37] | 2013 | Follicular variant of papillary thyroid carcinoma presenting as toxic nodule in an adolescent: coexistent polymorphism of the TSHR and Gsalpha genes. | Thyroid | 1 | 15 | AFTN | FVPTC |
Russo, D. et al. [70] | 1997 | Detection of an activating mutation of the thyrotropin receptor in a case of an autonomously hyperfunctioning thyroid insular carcinoma | JCEM | 1 | 60 | AFTN | Insular carcinoma |
Russo, D. et al. [69] | 1999 | A Val 677 activating mutation of the thyrotropin receptor in a Hurthle cell thyroid carcinoma associated with thyrotoxicosis | Thyroid | 1 | 42 | AFTN | Hurthle cell carcinoma |
Sablayrolles, B., et al. | 1983 | Thyroid carcinoma presenting as a hot nodule in a child | Archives Francaises De Pediatrie | 1 | |||
Salih, A. M., et al. | 2016 | Hyperfunctioning papillary thyroid carcinoma: A case report with literature review. | nternational Journal of Surgery Case Reports | 1 | 40 | TMNG | PTC |
Sandler, M. P., et al. [60] | 1988 | Thyroid carcinoma masquerading as a solitary benign hyperfunctioning nodule | Clinical Nuclear Medicine | 1 | AFTN | PTC | |
Sato, Y., et al. | 1998 | Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. | Endocrine Journal | 1 | 67 | TMNG | PTC |
Schmidt, S., et al. | 2016 | Hyperfunctioning thyroid nodules (toxic adenoma)-underestimated risk of malignancy? | Langenbeck’s Archives of Surgery | 1 | 72 | TMNG | PTC |
Schneider, P. W., et al. [61] | 2000 | A clear cell variant of follicular carcinoma presenting as an autonomously functioning thyroid nodule. | Thyroid | 1 | AFTN | FTC | |
Sevinc, B., et al. | 2018 | Papillary thyroid carcinoma after radioactive iodine treatment for toxic thyroid nodule: Case report. | Marmara Medical Journal | 1 | 55 | AFTN | PTC |
Siddiqui, A. R. and S. Karanauskas [38] | 1995 | Hurthle cell-carcinoma in an autonomous thyroid nodule in an adolescent | Pediatric Radiology | 1 | 16 | AFTN | Hurthle cell carcinoma |
Simsek, E., et al. | 2014 | Metastatic Papillary Thyroid Carcinoma in an Autonomous Hyperfunctioning Thyroid Nodule in an Adolescent | Endocrine Reviews | 1 | AFTN | PTC (metastatic) | |
Sobel, R. J., et al. | 1985 | Papillary carcinoma and the solitary autonomously functioning nodule of the thyroid. | Israel Journal of Medical Sciences | 3 | AFTN | PTC | |
Stahl, A., et al. [62] | 2002 | Differentiated thyroid carcinoma in a scintigraphically hot nodule: diagnosis and interdisciplinary therapeutical approach. | Wiener Klinische Wochenschrift | 1 | 57 | AFTN | Metastatic differentiated thyroid carcinoma |
Tangari, A., et al. [31] | 2011 | Hot nodule harboring a papillary microcarcinoma in a girl from an iodine sufficient area. | Hormone Research in Paediatrics | 1 | 3 | AFTN | PTC (microcarcinoma) |
Tfayli, H. M., et al. [39] | 2010 | Papillary thyroid carcinoma in an autonomous hyperfunctioning thyroid nodule: case report and review of the literature | Thyroid | 1 | 11 | AFTN | PTC |
Uludag, M., et al. | 2008 | Autonomously functioning thyroid nodule treated with radioactive iodine and later diagnosed as papillary thyroid cancer. | Hormones | 1 | 36 | AFTN | PTC (columnar type) |
Wong, C. P., et al. [63] | 2003 | Thyrotoxicosis: a rare presenting symptom of Hurthle cell carcinoma of the thyroid. | Clinical Nuclear Medicine | 1 | AFTN | Hurthle cell carcinoma |