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Table 1 Clinical characteristics and results of thyroid autoantibodies stratified by interval period over 35 years

From: Practice patterns and outcomes in the management of Thai patients with Graves’ disease

  Total
(N = 2736)
1985–1994
(N = 144)
1995–2004
(N = 416)
2005–2014
(N = 1209)
2015–2019
(N = 967)
Female (%) 82.0% 87.5% 85.6% 80.3% 81.7%
Age at diagnosis 36.3 + 12.0 33.0 + 9.7 34.7 + 10.9 36.0 + 12.4 37.8 + 12.1
- Age < 40 years 80.5% 72.2% 70.2% 66.9% 62.0%
- Age 40–59 years 35.8% 27.8% 28.6% 27.5% 32.3%
- Age ≥ 60 years 5.7% 1.2% 5.6% 5.7%
Family history of thyroid disorders (%) 41.2% 30.6% 38.0% 44.3% 40.1%
Smoking status (%)
 -Non-smoker 96.4% 97.9% 98.0% 96.7% 95.1%
 -Ex-smoker 0.9% 1.0% 0.7% 1.3%
 -Active smoker 2.7% 2.1% 1.0% 2.6% 3.5%
Weight status at initial presentation
 -Weight loss 85.0% 81.2% 83.9% 84.4% 86.8%
 -Weight neutral 11.6% 13.2% 13.0% 12.6% 9.5%
 -Weight gain 3.4% 5.6% 3.1% 3.0% 3.7%
Estimated thyroid size
 -Small 43.0% 25.0% 41.8% 46.4% 41.9%
 -Medium 41.5% 54.9% 42.6% 38.6% 42.6%
 -Huge 15.5% 20.1% 15.6% 15.0% 15.5%
Graves’ Ophthalmopathy(%)
 -No GO 83.9% 77.8% 79.3% 87.8% 81.9%
 -Mild GO 13.3% 21.5% 19.2% 9.6% 14.1%
 -Moderate to Severe GO 2.8% 0.7% 1.5% 2.6% 4.0%
 Pretibial myxedema 0.1% 0.1% 0.2%
 Thyrotoxic periodic paralysis (%) 2.3% 3.1% 1.8% 2.8%
Coexisting thyroid disease
 - Solitary thyroid nodule 2.2% 3.5% 1.7% 2.3% 2.1%
 `- Multinodular goiter 3.4% 2.1% 1.4% 3.4% 4.3%
 - Thyroid cancer 0.2% 0.2% 0.2% 0.3%
 Positive Anti-TPO (%)a 71.9% 73.8% 77.6% 75.8% 65.6%
 Positive Anti-Tg (%)b 61.3% 31.7% 53.6% 71.7% 52.4%
  1. aAvailable data 2071/2736 bAvailable data 2023/2736