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Table 1 Observational studies on the association between thyroid function and outcomes of venous thromboembolism (deep venous thrombosis and/or pulmonary embolism) in non-pregnant individuals

From: The interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review

Author

Yeara

Country

Design

Population (n)

Exposure assessment

Type of exposure

Associationb

Hyperthyroidism

 Dekkers et al. [41]

2017

Denmark

Cohort

932,913

Hospital diagnoses

Unspecified

 Segna et al. [42]

2016

Schwitzerland

Cohort

561

Biochemical

Subclinical

 Zöller et al. [43]

2012

Sweden

Cohort

535,538

Hospital diagnoses

Unspecified

 Ramagopalan et al. [44]

2011

United Kingdom

Cohort

4,310,042

Hospital diagnoses

Unspecified

 Lin et al. [45]

2010

Taiwan

Case-cohort

53,418

Hospital diagnoses

Unspecified

 Danescu et al. [46]

2009

United States

Cohort

908,805,000

Hospital diagnoses

Unspecified

 Squizzato et al. [47]

2007

Italy

Cross-sectional

150

Biochemical

Overt and subclinical

Hypothyroidism

 Segna et al. [42]

2016

Schwitzerland

Cohort

561

Biochemical

Subclinical

 Zöller et al. [43]

2012

Sweden

Cohort

535,538

Hospital diagnoses

Unspecified

 Ramagopalan et al. [44]

2011

United Kingdom

Cohort

4,869,188

Hospital diagnoses

Unspecified

 Danescu et al. [46]

2009

United States

Cohort

928,324,000

Hospital diagnoses

Unspecified

 Squizzato et al. [47]

2007

Italy

Cross-sectional

150

Biochemical

Overt and subclinical

Thyroid homone levels

 Lerstad et el [48].

2015

Norway

Cohort

11,962

Biochemical

TSH

 Debeij et al. [49]

2014

Netherlands

Case-control

5003

Biochemical

TSH and free T4

 Debeij et al. [50]

2012

Norway

Cohort

1991

Biochemical

TSH and free T4

 van Zaane et al. [51]

2009

Netherlands

Case-control

569

Biochemical

TSH, free T4, total T3

  1. Abbreviations: TSH Thyroid stimulating hormone, T4 Thyroxine, T3 Triiodothyronine
  2. aYear of publication
  3. bIndicates whether an association between the type of exposure and outcome of venous thromboembolism was observed, see text for details. ↑ higher risk, ↓ lower risk, − no association