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Table 1 Observational studies on the association between thyroid function and outcomes of venous thromboembolism (deep venous thrombosis and/or pulmonary embolism) in non-pregnant individuals

From: The interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review

Author Yeara Country Design Population (n) Exposure assessment Type of exposure Associationb
Hyperthyroidism
 Dekkers et al. [41] 2017 Denmark Cohort 932,913 Hospital diagnoses Unspecified ↑
 Segna et al. [42] 2016 Schwitzerland Cohort 561 Biochemical Subclinical ↓
 Zöller et al. [43] 2012 Sweden Cohort 535,538 Hospital diagnoses Unspecified ↑
 Ramagopalan et al. [44] 2011 United Kingdom Cohort 4,310,042 Hospital diagnoses Unspecified ↑
 Lin et al. [45] 2010 Taiwan Case-cohort 53,418 Hospital diagnoses Unspecified ↑
 Danescu et al. [46] 2009 United States Cohort 908,805,000 Hospital diagnoses Unspecified –
 Squizzato et al. [47] 2007 Italy Cross-sectional 150 Biochemical Overt and subclinical –
Hypothyroidism
 Segna et al. [42] 2016 Schwitzerland Cohort 561 Biochemical Subclinical –
 Zöller et al. [43] 2012 Sweden Cohort 535,538 Hospital diagnoses Unspecified ↑
 Ramagopalan et al. [44] 2011 United Kingdom Cohort 4,869,188 Hospital diagnoses Unspecified ↑
 Danescu et al. [46] 2009 United States Cohort 928,324,000 Hospital diagnoses Unspecified ↑
 Squizzato et al. [47] 2007 Italy Cross-sectional 150 Biochemical Overt and subclinical ↑
Thyroid homone levels
 Lerstad et el [48]. 2015 Norway Cohort 11,962 Biochemical TSH ↑
 Debeij et al. [49] 2014 Netherlands Case-control 5003 Biochemical TSH and free T4 ↑
 Debeij et al. [50] 2012 Norway Cohort 1991 Biochemical TSH and free T4 ↑
 van Zaane et al. [51] 2009 Netherlands Case-control 569 Biochemical TSH, free T4, total T3 ↑
  1. Abbreviations: TSH Thyroid stimulating hormone, T4 Thyroxine, T3 Triiodothyronine
  2. aYear of publication
  3. bIndicates whether an association between the type of exposure and outcome of venous thromboembolism was observed, see text for details. ↑ higher risk, ↓ lower risk, − no association
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Thyroid Research

ISSN: 1756-6614