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Table 1 Association between transient congenital hypothyroidism (CH) and potential risk factors

From: Risk factors for transient and permanent congenital hypothyroidism: a population-based case-control study

Variable Control
N = 340
Transient CH
N = 204
OR (95% CI) P value*
Gestational age (week)
  ≤ 37 310 153 3.44 (2.1–5.62) 0.001
  > 37 30 51 1
Birth length (cm)
  ≤ 50 100 53 1.18 (0.8–1.75) 0.223
  > 50 240 151 1
Parental consanguineous marriage
 No 296 (87.1) 161 (78.9) 1 1
 Yes 44 (12.9) 43 (21.1) 2.17 (1.57–3) 0.001
Betadine usage
 No 336 (98.2) 191 (93.6) 1 1
 Yes 4 (1.2) 13 (6.4) 5.62 (1.8–17.5) 0.003
Gender
 Male 181 (53.2) 109 (53.4) 1 1
 Female 159 (46.8) 95 (46.6) (0.72–1.4) 0.97
History of CH in the first degree
 No 335 (98.5) 188 (92.2) 1 1
 Yes 5 (1.5) 16 (7.8) 5.6 (2.02–15.5) 0.001
Neonatal jaundice
 No 299 (87.9) 141 (69.1) 1 1
 Yes 41 (12.1) 63 (30.9) 3.53 (2.26–5.51) 0.001
Birth weight (gr)
  < 2500 19 (5.6) 23 (11.3) 1 1
 4000–2500 308 (90.6) 174 (85.3) 0.39 (0.22–0.69) 0.01
  > 2500 13 (3.8) 7 (3.4) 0.39 (0.15–1.3) 0.058
Mother’s age (year)
  < 20 43 (12.6) 22 (10.8) 1 1
 20–30 97 (28.5) 77 (37.7) 1.6 (0.89–2.94) 0.1
 30–40 127 (37.4) 78 (38.2) 1.2 (0.36–1.42) 0.54
  > 40 73 (21.5) 27 (13.2) 0.74 (0.78–1.45) 0.34
  1. * Χ2 test was used in the all tests