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Table 1 Detection and characterization of interference using polyethylene glycol, heterophilic blocking tube, and streptavidin-coated magnetic particle SA-MP treatment

From: Falsely diagnosed thyrotoxicosis caused by anti-streptavidin antibodies and pre-wash procedures

  TSH, μIU/mL (RR: 0.50–5.00) FT4, ng/dL (RR: 0.90–1.70) FT3, pg/mL (RR: 2.3–4.0)
Patient
 Before PEG Tx 4.67 2.66 5.88
 After PEG Tx (actual measured value) 4.77 0.87 2.11
 After PEG Tx (calculated value) 9.54
  TSH FT4 FT3
 Recovery (%) 204 (RR: 30–80) 33 (RR: 60–90) 36 (RR: 60–90)
  TSH, μIU/mL (RR: 0.50–5.00) FT4, ng/dL (RR: 0.90–1.70) FT3, pg/mL (RR: 2.3–4.0)
Patient
 Before HBT Tx or SA-MP Tx 4.36 2.15 4.27
 After HBT Tx 6.49 1.68 3.86
 After SA-MP Tx 9.81 1.04 2.7
Control
 Before HBT Tx and SA-MP Tx 3.65 1.63 3.62
 After HBT Tx 3.69 1.64 3.64
 After SA-MP Tx 3.64 1.66 3.61
  1. PEG Tx resulted in a high TSH level but low FT4 and FT3 recovery. HBT Tx or SA-MP Tx resulted in a higher TSH but lower FT4 and FT3 values. However, HBT Tx or SA-MP Tx showed almost the same results in the control sample