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Table 2 Hazard ratio for variables associated with relapse (A) and death (B) in PTC cohort

From: Development of metastatic poorly differentiated thyroid cancer from a sub-centimeter papillary thyroid carcinoma in a young patient with a germline MET mutation – association or random chance?

Covariate

Univariate analyses

Multivariate analyses

Coefficient

HR (95% CI)

P value

Coefficient

HR (95% CI)

P value

A

 Up-regulated MET expression

–0.215

0.807 (0.216–3.014)

0.749

0.453

1.573 (0.337–7.329)

0.564

  Older age

–0.014

0.987 (0.263–3.703)

0.984

–0.142

0.868 (0.179–4.213)

0.860

  T-stage

0.970

2.639 (1.135–6.134)

0.024

1.272

3.569 (1.315–9.684)

0.012

  BRAF V600E mutation

–0.245

0.782 (0.195–3.135)

0.729

0.289

1.335 (0.239–7.473)

0.742

  TERT promoter mutation

–3.871

0.021 (0.195–3.935)

0.006

5.560

259.887 (5.837–11,571.576)

0.004

B

 Up-regulated MET expression

–4.195

0.015 (0.000–20.262)

0.254

–12.212

0.000 (0.000–1.647E + 217)

0.964

  Age at diagnosis

0.428

1.53 (0.256–9.191)

0.640

0.062

1.064 (0.139–8.153)

0.952

  T-stage

1.133

–3.1 (0.981–9.829)

0.054

1.487

4.423 (0.945–20.711)

0.009

  BRAF V600E mutation

–0.461

0.631 (0.105–3.785)

0.614

0.118

1.126 (0.101–12.498)

0.923

  TERT promoter mutation

–3.178

23.995 (2.176–264.647)

0.009

4.140

62.818 (1.578–2501.380)

0.028

  1. Significant p-values are in bold
  2. Abbreviations: HR Hazard ratio, CI Confidence interval
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Thyroid Research

ISSN: 1756-6614