Table 1 Study eligibility and exclusion criteria
Inclusion criteria | |
|---|---|
Design | All observational studies such as case-control and cohort studies |
Participants | All adult patients (≥ 18 years old) who have a laboratory-confirmed diagnosis of COVID-19 with information on thyroid disease (any thyroid disorders such as hypothyroidism and hyperthyroidism with or without treatment (being euthyroid or not) and thyroid cancer with or without radioiodine therapy) |
Comparison/exposure | Thyroid disorders such as hypothyroidism and hyperthyroidism with or without treatment (being euthyroid or not) and thyroid cancer with or without radioiodine therapy are evaluated as factors affecting the clinical outcomes and prognosis COVID −19 disease. |
Outcomes | The outcome of interest will be any clinical outcomes in patients with COVID-19, including mortality, severe COVID-19, ARDS, duration of hospitalization, need for ICU care/ admission to ICU, and disease progression |
Exclusion criteria | •. irrelevant study design, including review articles, letters, commentaries or case reports and case series with COVID-19 patients below 20 •. observational studies that examined risk factors for adverse clinical outcomes in patients infected by other coronaviruses (e.g., Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome) •. observational studies on the association between Covid-19 and non-thyroidal illness or sub-acute thyroiditis •. irrelevant study population (<  18 years old) |