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Table 5 Objective Response Rate Among Patients With Advanced Medullary Thyroid Cancer

From: Diagnostic characteristics, treatment patterns, and clinical outcomes for patients with advanced/metastatic medullary thyroid cancer

 

All Patients

Patients With RET-Mutant MTC

During First-Line Therapy

During Second-Line Therapy

During First-Line Therapy

During Second-Line Therapy

Objective response (complete or partial response) (n, %)

129

63.5%

19

38.8%

28

62.2%

8

61.5%

Among those who had objective response and known date of objective response, duration of response (n) a

71

6

12

3

Mean (SE)

15.4 (1.2)

16.8 (–)

8.4 (0.9)

NE

Median

NE

NE

NE

 

95% CI

10.3

NE

16.8

 

4.2

NE

  

Q1, Q3

6

NE

16.8

 

6.6

NE

  

Censored (n, %)

46

64.8%

5

83.3%

7

58.3%

3

100.0%

  1. CI confidence interval, MTC medullary thyroid cancer, NE not estimable, Q1 first quartile, Q3 third quartile, RET rearranged during transfection, SE standard error
  2. aDuration of objective response defined as time from complete or partial response to disease progression, death, or start of next line of treatment. Patients with treatment line ongoing or who discontinued treatment for nonprogression reasons were censored
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Thyroid Research

ISSN: 1756-6614