Hypothyroidism in hibernating brown bears

Table 2 Regulations in thyroid hormone levels and in mRNA levels of the major thyroid hormone-binding proteins

			Winter/summer ratio Median (range) of paired samples
	Active state (nM) Median (range)	Hibernation (nM) Median (range)	Log₂(FC)	FC (%)	P	Method
T₄	13.6 (7.39 to 19.76)	< 5.4 (< 5.4 to 9.68)	-1.20 (-1.87 to -0.15)	44* (27 to 90)	0.008	Immuno-assay
T₃	0.82 (0.68 to 1.06)	< 0.3 (< 0.3 to < 0.3)	-1.46 (-1.18 to -1.82)	36* (28 to 44)	0.016	Immuno-assay
TBG	−	−	2.17 (1.24 to 6.37)	449* (237 to 8243)	0.031	RNA-seq
TTR	−	−	0.49 (-0.26 to 0.56)	140 (84 to 147)	0.156	RNA-seq
Albumin	−	−	0.27 (0.17 to 0.53)	121* (113 to 144)	0.031	RNA-seq

Summary of regulations in the thyroid hormone levels in brown bear serum samples and in the mRNA levels of the major thyroid hormone-binding proteins in grizzly bear liver samples from active state and hibernation. *Significant difference (P < 0.05)

ISSN: 1756-6614