Table 1 Expression of somatostatin receptors subtypes in some thyroid lesions – the previous studies
Lesion type | SSTR detected | Material | Methods | Authors |
|---|---|---|---|---|
Follicular carcinoma | SSTR 1, 2A, 2B, 4, 5 -100%, SSTR 3-negative. | Formalin fixed paraffin embedded sections. | IHC | [12] |
SSTR 1, 3 -moderate, SSTR 2-faint, SSTR 5-strong, SSTR 4-negative. | Thyroid cancer cell line monolayer and xenograft (MRO-87, WRO-82). | Semiquantitative RT-PCR with ethidium bromide. | [10] | |
Papillary carcinoma | SSTR 1, 2B, 3, 4 -83%; SSTR 2A-66%, SSTR 5–100%. | Formalin fixed paraffin embedded sections. | IHC | [12] |
SSTR 1, 3, 5 -moderate, SSTR 2 – faintly detectable, SSTR 4 – negative. | Thyroid cancer cell line monolayer and xenograft (NPA 87, KAT-10). | Semiquantitative RT-PCR with ethidium bromide. | [10] | |
SSTR 2 -87%. | Paraffin embedded sections. | IHC | [13] | |
SSTR 2–68%, SSTR 5–50%, SSTR3 -31%, SSTR 1, 4 – not found. | Frozen tissue. | RT-PCR | [13] | |
SSTR 1, 3, 4, 5-more than twice the background, SSTR 2 -no signal. | Frozen biopsied tumor tissue. | Northern blot analysis. | [21] | |
Multinodular goiter (MNG) | SSTR 2A, 3, 4 -82%, SSTR 2B, 5–94%, SSTR 1–88%. | Formalin fixed paraffin embedded sections. | IHC | [12] |