Skip to main content

Table 1 Expression of somatostatin receptors subtypes in some thyroid lesions – the previous studies

From: Expression of somatostatin receptor subtypes in human thyroid tumors: the immunohistochemical and molecular biology (RT-PCR) investigation

Lesion type SSTR detected Material Methods Authors
Follicular carcinoma SSTR 1, 2A, 2B, 4, 5 -100%, SSTR 3-negative. Formalin fixed paraffin embedded sections. IHC [12]
  SSTR 1, 3 -moderate, SSTR 2-faint, SSTR 5-strong, SSTR 4-negative. Thyroid cancer cell line monolayer and xenograft (MRO-87, WRO-82). Semiquantitative RT-PCR with ethidium bromide. [10]
Papillary carcinoma SSTR 1, 2B, 3, 4 -83%; SSTR 2A-66%, SSTR 5–100%. Formalin fixed paraffin embedded sections. IHC [12]
  SSTR 1, 3, 5 -moderate, SSTR 2 – faintly detectable, SSTR 4 – negative. Thyroid cancer cell line monolayer and xenograft (NPA 87, KAT-10). Semiquantitative RT-PCR with ethidium bromide. [10]
  SSTR 2 -87%. Paraffin embedded sections. IHC [13]
  SSTR 2–68%, SSTR 5–50%, SSTR3 -31%, SSTR 1, 4 – not found. Frozen tissue. RT-PCR [13]
  SSTR 1, 3, 4, 5-more than twice the background, SSTR 2 -no signal. Frozen biopsied tumor tissue. Northern blot analysis. [21]
Multinodular goiter (MNG) SSTR 2A, 3, 4 -82%, SSTR 2B, 5–94%, SSTR 1–88%. Formalin fixed paraffin embedded sections. IHC [12]