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  1. Carcinoma showing thymus-like differentiation (CASTLE) in the thyroid gland is a rare disease with generally a favorable prognosis. Treatment with surgery and adjuvant radiotherapy has been shown to improve lo...

    Authors: N. V. Dang, L. X. Son, N. T. T. Hong, N. T. T. Nhung, N. T. Tung and L. V. Quang

    Citation: Thyroid Research 2021 14:20

    Content type: Case report

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  2. Thyroid cancer dedifferentiation is an unusual observation among young patients and is poorly understood, although a recent correlation to DICER1 gene mutations has been proposed.

    Authors: Klara Johansson, Adam Stenman, Johan O. Paulsson, Na Wang, Catharina Ihre-Lundgren, Jan Zedenius and C. Christofer Juhlin

    Citation: Thyroid Research 2021 14:19

    Content type: Case report

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  3. Anti-streptavidin antibodies are causal determinants of analytical interference during Thyroid function tests, and numerous reports have detailed such interference, with anti-streptavidin antibodies attracting...

    Authors: Takuya Ishikawa, Hiroyuki Sakai, Tokutaro Itaya, Suwanai Hirotsugu, Jumpei Shikuma, Takashi Miwa, Ryo Suzuki and Masato Odawara

    Citation: Thyroid Research 2021 14:17

    Content type: Case report

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  4. Ultrasound is the first-line imaging modality for detection and classification of thyroid nodules. Certain characteristics observable by ultrasound have recently been identified that may indicate malignancy. T...

    Authors: Michael Cordes, Theresa Ida Götz, Elmar Wolfgang Lang, Stephan Coerper, Torsten Kuwert and Christian Schmidkonz

    Citation: Thyroid Research 2021 14:16

    Content type: Research

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  5. Distant metastasis from papillary thyroid microcarcinoma (PTMC) is rare. Here we report a case of PTMC with multiple lung metastases.

    Authors: Tadafumi Shimizu, Takaaki Oba, Tatsunori Chino, Ai Soma, Mayu Ono, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno, Yoshinori Sato, Takeshi Uehara and Ken-ichi Ito

    Citation: Thyroid Research 2021 14:15

    Content type: Case report

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  6. Mild to moderate iodine deficiency during pregnancy has been associated with adverse neurodevelopmental outcomes in offspring. Few research studies to date combine assessment of urinary iodine (UIC and/or ICr)...

    Authors: Anna M. Monaghan, Maria S. Mulhern, Emeir M. McSorley, J. J. Strain, Matthew Dyer, Edwin van Wijngaarden and Alison J. Yeates

    Citation: Thyroid Research 2021 14:14

    Content type: Review

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  7. Hypocalcemia is one of the main complications of thyroid surgery. We hypothesized that hemithyroidectomy may have an impact on serum parathyroid hormone (PTH) and calcium levels despite only one thyroid lobe i...

    Authors: Isabel Fernández Palop, Cristina Fernández Martínez, María Jesús Segura Giménez, M. Carmen Azorin Samper and Rafael García Fuster

    Citation: Thyroid Research 2021 14:13

    Content type: Research

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  8. Pregnancy induces physiological changes that affect the risk of thrombosis and thyroid disease. In this hypothesis-generating review, the physiological changes in the coagulation system and in thyroid function...

    Authors: Stine Linding Andersen, Kasper Krogh Nielsen and Søren Risom Kristensen

    Citation: Thyroid Research 2021 14:12

    Content type: Review

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  9. Congenital hypothyroidism (CH) is the most important cause of mental and physical retardation in newborns. The prevalence of CH has been reported high in East Azerbaijan province of Iran. However, the risk fac...

    Authors: Fariba Abbasi, Leila Janani, Malihe Talebi, Hosein Azizi, Lotfali Hagiri and Shahnaz Rimaz

    Citation: Thyroid Research 2021 14:11

    Content type: Research

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  10. Thyroglobulin (Tg) is a specific tumor marker for differentiated thyroid cancer (DTC). However, in the presence of an antithyroglobulin antibody (TgAb), it becomes unreliable. The purpose of the study was to a...

    Authors: Manish Ora, Aftab Hasan Nazar, Prabhakar Mishra, Sukanta Barai, Amitabh Arya, Prasanta Kumar Pradhan and Sanjay Gambhir

    Citation: Thyroid Research 2021 14:8

    Content type: Research

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  11. Fine needle aspiration (FNA) cytology, the gold standard in assessing thyroid nodules, is limited by its inability to determine the true risk of malignancy in Thy 3 nodules. Most patients with Thy3 cytology un...

    Authors: Giorgos Pikis, Eleni Kandaraki, Demetris Lamnisos, Sereen Abbara, Katerina Kyriakou, Aliki Economides and Panayiotis A. Economides

    Citation: Thyroid Research 2021 14:7

    Content type: Research

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  12. The ovarian function and therefore the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto’s thyroiditis (HT) is the most common in women of reproductive age. Furt...

    Authors: Felipe A. Morales-Martínez, Luis H. Sordia-Hernández, Martha Merino Ruiz, Selene Garcia-Luna, Otto H. Valdés-Martínez and Oscar Vidal-Gutierez

    Citation: Thyroid Research 2021 14:6

    Content type: Short report

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  13. The treatment of hyperthyroid Graves’ disease (GD) varies considerably among geographic areas. In this study, we aimed to evaluate practice patterns and treatment outcomes in Thai patients with hyperthyroid GD.

    Authors: Yotsapon Thewjitcharoen, Krittadhee Karndumri, Waralee Chatchomchuan, Sriurai Porramatikul, Sirinate Krittiyawong, Ekgaluck Wanathayanoroj, Nampetch Lekpittaya, Worawit Kittipoom, Tawee Anuntakulnatee, Somboon Vongterapak, Siriwan Butadej, Soontaree Nakasatien, Rajata Rajatanavin and Thep Himathongkam

    Citation: Thyroid Research 2021 14:5

    Content type: Research

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  14. Pretibial myxedema also known as localized myxedema, thyroid dermopathy, or infiltrative dermopathy and rarely as localized mucinosis is an infrequent manifestation of Graves’ disease. It can appear before, du...

    Authors: Rediet Ambachew, Tizita Yosef, Aklilu M. Gebremariam, Lishan Demere, Theodros Aberra, Getahun Tarekegn and Ahmed Reja

    Citation: Thyroid Research 2021 14:4

    Content type: Case report

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  15. Hyperfunctioning or hot nodules are thought to be rarely malignant. As such, current guidelines recommend that hot nodules be excluded from further malignancy risk stratification. The objective of this systema...

    Authors: Lorraine W. Lau, Sana Ghaznavi, Alexandra D. Frolkis, Alexandra Stephenson, Helen Lee Robertson, Doreen M. Rabi and Ralf Paschke

    Citation: Thyroid Research 2021 14:3

    Content type: Research

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  16. Thyroid nodules are common in clinical practice, and it is important to distinguish benign nodules, the vast majority, from malignant ones. Non-diagnostic (ND) samples have the potential to delay or mis-diagno...

    Authors: Devon Houdek, Sandra Cooke-Hubley, Lakshmi Puttagunta and Donald Morrish

    Citation: Thyroid Research 2021 14:2

    Content type: Research

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  17. Anaplastic thyroid cancer (ATC) is undoubtedly the thyroid cancer histotype with the poorest prognosis. The conventional treatment includes surgery, radiotherapy, and conventional chemotherapy. Surgery should ...

    Authors: Simone De Leo, Matteo Trevisan and Laura Fugazzola

    Citation: Thyroid Research 2020 13:17

    Content type: Review

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  18. 131-iodine (131I) administration after surgery remains a standard practice in differentiated thyroid cancer (DTC). In 2014, the American Thyroid Association presented new guidelines for the staging and management...

    Authors: Laura Iconaru, Felicia Baleanu, Georgiana Taujan, Ruth Duttmann, Linda Spinato, Rafik Karmali, Pierre Bergmann and Anne-Sophie Hambye

    Citation: Thyroid Research 2020 13:15

    Content type: Research

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  19. Total T4 (TT4) measurement is preferred to free T4 (FT4) especially in last part of pregnancy. Guidelines by American Thyroid Association, European Thyroid Association and Endocrine Society state that TT4 incr...

    Authors: Subhodip Pramanik, Pradip Mukhopadhyay and Sujoy Ghosh

    Citation: Thyroid Research 2020 13:14

    Content type: Short report

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  20. Our previous kinetic analyses of changes in the tumor volume (TV) of papillary thyroid microcarcinomas during active surveillance revealed that the tumors’ growth varied over time from rather rapid growth to s...

    Authors: Minoru Kihara, Akira Miyauchi, Hiroo Masuoka, Takuya Higashiyama, Yasuhiro Ito and Akihiro Miya

    Citation: Thyroid Research 2020 13:13

    Content type: Research

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  21. Antithyroid drugs (ATDs) are preferred for the treatment of hyperthyroidism caused by Graves’ disease in pregnant women. The drugs have been a recognized treatment for decades, and a general risk of side effec...

    Authors: Stine Linding Andersen and Stig Andersen

    Citation: Thyroid Research 2020 13:11

    Content type: Review

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  22. Subclinical hypothyroidism is defined as elevated TSH levels while T4 or FT4 levels are normal. Elevated TSH levels are linked with obesity in adults. In a recent meta-analysis in Iran, 6.1% of children below ...

    Authors: Ashkan Habib, Mohadeseh Molayemat and Asadollah Habib

    Citation: Thyroid Research 2020 13:9

    Content type: Research

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  23. The prevalence of thyroid cancer is increasing worldwide. No previous data are available on the prevalence of thyroid cancer in Yemen. We performed this study to determine the prevalence of thyroid cancer amon...

    Authors: Butheinah A. Al-Sharafi, Jamila A. AlSanabani, Ibraheem M. Alboany and Amani M. Shamsher

    Citation: Thyroid Research 2020 13:8

    Content type: Research

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  24. Worldwide, hypothyroidism affects 3.7% of the population, and is associated with impaired quality of life. This study aimed to evaluate the effect of cognitive- behavioral therapy (CBT) on the quality of life ...

    Authors: Sohaila Rezaei, Parvin Abedi, Elham Maraghi, Najmeh Hamid and Homaira Rashidi

    Citation: Thyroid Research 2020 13:6

    Content type: Research

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  25. Levothyroxine (LT4) pseudomalabsorption due to medication non-adherence results in significant costs for Health Service. High dose LT4 or LT4/paracetamol absorption test is used in such cases. Hence, establishmen...

    Authors: Krzysztof C. Lewandowski, Katarzyna Dąbrowska, Magdalena Basińska-Lewandowska, Marek Bolanowski, Marek Ruchała and Andrzej Lewiński

    Citation: Thyroid Research 2020 13:5

    Content type: Case report

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  26. Thyrotoxicosis is common disorder among endocrine dysfunctions. It is not rare that the free thyroid hormone level exceeds the measurement range of immunoassay. Such extreme high concentration of free thyroid ...

    Authors: Yuko Ito, Satoru Suzuki, Yoshiko Matsumoto, Chiyo Ohkouchi, Satoshi Suzuki, Manabu Iwadate, Sanae Midorikawa, Susumu Yokoya, Shinichi Suzuki and Hiroki Shimura

    Citation: Thyroid Research 2020 13:4

    Content type: Case report

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  27. Anti-Müllerian hormone (AMH) decreases acutely after post-surgical radioactive iodine (RAI) ablation in females with differentiated thyroid cancer (DTC).

    Authors: Miranda Mittica, Andrea Dotto, Martina Comina, Marsida Teliti, Eleonora Monti and Massimo Giusti

    Citation: Thyroid Research 2020 13:1

    Content type: Research

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  28. Treatment of moderate to severe Graves’ orbitopathy (GO) is based mainly on intravenous pulses of methylprednisolone. High doses of methylprednisolone can exert several adverse effects, some of which might be ...

    Authors: Dorota Walasik-Szemplińska, Grzegorz Kamiński and Iwona Sudoł-Szopińska

    Citation: Thyroid Research 2019 12:13

    Content type: Review

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  29. Thyroid swellings enlarge caudally into the mediastinum behind the sternum. Pre-sternal swelling of thyroid origin is very rare. We present our case of pre-sternal thyroid swelling which was albeit a surprisin...

    Authors: Lovenish Bains, Sushant Bhatia, Rohit Kaushik, Sudhir Kumar Jain, Chandra Bhushan Singh, Shramana Mandal and Daljit Kaur

    Citation: Thyroid Research 2019 12:12

    Content type: Case report

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  30. Well-differentiated thyroid carcinoma is defined as locally advanced in the presence of an extra thyroid extension, e.g., when the surrounding structures such as the trachea, larynx, esophagus and main blood v...

    Authors: Alessio Metere, Valerio Aceti and Laura Giacomelli

    Citation: Thyroid Research 2019 12:10

    Content type: Review

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  31. A high body fat percentage has a specific effect on activation of the hypothalamic-pituitary-thyroid axis. On the other hand, a slight change in thyroid hormones can affect metabolism and body composition as w...

    Authors: Maryam Karkhaneh, Mostafa Qorbani, Asal Ataie-Jafari, Mohamad Reza Mohajeri-Tehrani, Hamid Asayesh and Saeed Hosseini

    Citation: Thyroid Research 2019 12:9

    Content type: Research

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  32. Resistance to thyroid hormone (RTH) usually features a syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH) without suppression of the typical high thyroid hormone levels. However, some p...

    Authors: Tomoko Nagamine, Jaeduk Yoshimura Noh, Naoya Emoto, Takahito Kogai, Akira Hishinuma, Fumitaka Okajima and Hitoshi Sugihara

    Citation: Thyroid Research 2019 12:8

    Content type: Case report

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  33. Resistance to thyroid hormones is a very rare condition, which is often misdiagnosed and mistreated. The cases where there is a concomitant autoimmune thyroid disorder are ultra-rare and particularly challengi...

    Authors: Todor Arsov, Chengmei Xie, Nan Shen, Dan Andrews, Carola G. Vinuesa and Olivija Vaskova

    Citation: Thyroid Research 2019 12:7

    Content type: Case report

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  34. Aberrant iodine intake and thyroid autoimmunity affect thyroid function. Deficiencies of iodine including thyroid disorders have serious impact on child physical and mental development. This study was conducte...

    Authors: Binaya Tamang, Saroj Khatiwada, Basanta Gelal, Shrijana Shrestha, Kishun Deo Mehta, Nirmal Baral, Gauri Shankar Shah and Madhab Lamsal

    Citation: Thyroid Research 2019 12:6

    Content type: Research

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  35. To semi-quantitatively analyze liver uptake of I-131 in diagnostic and post-therapy scans by calculating hepatic to thigh ratios (HTR) and evaluate its clinical significance in management of differentiated thy...

    Authors: Prasanta K. Pradhan, Suruchi Jain, Madhusudhanan Ponnuswamy, Amitabh Arya and Manish Ora

    Citation: Thyroid Research 2019 12:4

    Content type: Research

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  36. Thyrotoxicosis is a clinical state that results from inappropriately high thyroid hormone action in tissues. Although it is one of the common endocrine disorders, there is scarcity of data on the management of...

    Authors: Eyob Alemayehu Gebreyohannes, Emneteab Mesfin Ayele, Soliana Alemayehu Tesfaye and Mohammed Assen Seid

    Citation: Thyroid Research 2019 12:3

    Content type: Research

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  37. Both overt hypothyroidism as well as minor elevations of serum thyrotropin (TSH) levels associated with thyroid hormones within their respective reference ranges (termed subclinical hypothyroidism) are relativ...

    Authors: Owain Leng and Salman Razvi

    Citation: Thyroid Research 2019 12:2

    Content type: Review

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