Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases

Autoimmune thyroid disorders (AITD) broadly include Graves’ disease and Hashimoto’s thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactio...

Authors: Marta Rydzewska, Michał Jaromin, Izabela Elżbieta Pasierowska, Karlina Stożek and Artur Bossowski

Management of hypothyroidism with combination thyroxine (T4) and triiodothyronine (T3) hormone replacement in clinical practice: a review of suggested guidance

Whilst trials of combination levothyroxine/liothyronine therapy versus levothyroxine monotherapy for thyroid hormone replacement have not shown any superiority, there remains a small subset of patients who do ...

Authors: Colin Dayan and Vijay Panicker

Papillary thyroid cancer recurrence 43 Years following Total Thyroidectomy and radioactive iodine ablation: a case report

Recurrent papillary thyroid carcinoma (PTC) beyond the first two decades of definitive treatment (i.e. total thyroidectomy and radioactive iodine ablation) is a rare occurrence.

Authors: Yaw Amoako-Tuffour, M. Elise Graham, Martin Bullock, Matthew H. Rigby, Jonathan Trites, S. Mark Taylor and Robert D. Hart

Hyalinizing trabecular tumor of the thyroid gland and its significant diagnostic issue

Hyalinizing trabecular tumors (HTT) are rare follicular cell-derived tumors of the thyroid gland that are infrequently reported in otolaryngology literature. We present here an interesting case of HTT which pr...

Authors: Dustin J. Jones, Christopher R. Kieliszak, Sanjay S. Patel and Christopher R. Selinsky

A retrospective review of the multidisciplinary management of medullary thyroid cancer: eligibility for systemic therapy

Medullary thyroid carcinoma (MTC) accounts for 1-2% of all thyroid cancers. The clinical course of metastatic disease can be indolent. Our aim was to characterize the natural history of disease to evaluate the...

Authors: Georgia Geller, Janessa Laskin, Winson Y. Cheung and Cheryl Ho

Meeting abstracts from the 65th British Thyroid Association Annual Meeting

Authors:

Comparative frequency of four different types of pregnancy-associated thyrotoxicosis in a single thyroid centre

Pregnancy and delivery markedly influence thyroid function. However, the comparative prevalence of gestational thyrotoxicosis (GT), new onset of Graves’ disease during pregnancy (GD during pregnancy), postpart...

Authors: Akane Ide, Nobuyuki Amino, Takumi Kudo, Waka Yoshioka, Mako Hisakado, Eijun Nishihara, Mitsuru Ito, Shuji Fukata, Hirotoshi Nakamura and Akira Miyauchi

Malignant Struma ovarii in a 30-year old nulliparous patient

Struma ovarii is a rare monodermal germ cell tumor where the ovary is comprised of at least half thyroid tissue. This phenomenon may indicate an embryological origin.

Authors: J. Colin Boyd, Blair A. Williams, Matthew H. Rigby, Katharina Kieser, Saul Offman, Hemlata Shirsat, Jonathan R. B. Trites, S. Mark Taylor and Robert D. Hart

Meeting abstracts from the 64th British Thyroid Association Annual Meeting

Authors: Luigi Bartalena, Eric Fliers, Nicola Hellen, Peter N. Taylor, Arron Lacey, Daniel Thayer, Mohd Draman Yusof, Arshiya Tabasum, Illaria Muller, Luke Marsh, Marian Ludgate, Alex Rees, Kristien Boelaert, Shiao Chan, Scott Nelson, Aled Rees…

Concordance between the TIRADS ultrasound criteria and the BETHESDA cytology criteria on the nontoxic thyroid nodule

Thyroid nodule is a common disorder of the thyroid. Despite their benign nature, they can be associated with multiple pathologic conditions, including thyroid cancer.

Authors: Hernando Vargas-Uricoechea, Ivonne Meza-Cabrera and Jorge Herrera-Chaparro

Abstracts and short papers from the 5th Congress of the Polish Thyroid Association, Poznan, 3-5 September, 2015

Authors: Leonard Wartofsky, Peter Smyth, Josef Köhrle, Ryszard Anielski, Marian Slowiaczek, Pawel Orlicki, Rafal Czepczynski, Jacek Daroszewski, Alicja Hubalewska-Dydejczyk, Aldona Kowalska, Maria Kurowska, Joanna Malicka, Anna Oszywa-Chabros, Agnieszka Zwolak, Jerzy S. Tarach, Krzysztof C. Lewandowski…

Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) – results from the feasibility randomised controlled trial

Hypothyroidism is a common condition, particularly in the older population. Thyroid hormone requirements change with age and serum TSH levels also alter, especially in older patients. However, in practice labo...

Authors: Salman Razvi, Lorna Ingoe, Vicky Ryan, Simon H. S. Pearce and Scott Wilkes

Predicting malignancy in thyroid nodules: feasibility of a predictive model integrating clinical, biochemical, and ultrasound characteristics

Although the majority of thyroid nodules are benign the process of excluding malignancy is challenging and sometimes involves unnecessary surgical procedures. We explored the development of a predictive model ...

Authors: Justyna Witczak, Peter Taylor, Jason Chai, Bethan Amphlett, Jean-Marc Soukias, Gautam Das, Brian P. Tennant, John Geen and Onyebuchi E. Okosieme

Thyroid research: stepping forward

It is eight years since Thyroid Research was launched with an aim to enhance opportunities for scientists and clinicians, working in the rapidly advancing field of thyroidology, to publish their research (Thyroid...

Authors: Bijay Vaidya and Andrzej Lewinski

Association between iron status and thyroid function in Nepalese children

Deficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hil...

Authors: Saroj Khatiwada, Basanta Gelal, Nirmal Baral and Madhab Lamsal

Pendulum swings from hypo- to hyperthyroidism: thyrotoxicosis after severe hypothyroidism following neck irradiation in a patient with a history of Hodgkin’s lymphoma

A change in a thyrometabolic state from severe hypothyroidism to thyrotoxicosis is very uncommon, but possible in some circumstances.

Authors: Krzysztof Lewandowski, Katarzyna Dąbrowska, Jacek Makarewicz and Andrzej Lewiński

Iodine prophylaxis in pregnant women in Poland - where we are? (update 2015)

Introduction of the model of iodine prophylaxis based on the consumption of iodized salt in 1997 has eliminated the iodine deficiency in Poland. However, in accordance with the current recommendations, all wom...

Authors: Arkadiusz Zygmunt and Andrzej Lewinski

A single bolus of high dose levothyroxine (L-T₄) as a test in cases of suspected poor compliance to L-T4 therapy

Though compliance (or adherence) problems, as well as inappropriate levothyroxine (L-T₄) intake (e.g. with meal, other drugs or certain foods that can significantly affect absorption) are very common, the issue i...

Authors: Krzysztof C. Lewandowski, Katarzyna Dąbrowska, Iwona Komorowska-Dudek and Andrzej Lewiński

A systematic review and meta-analysis of Harmonic Focus in thyroidectomy compared to conventional techniques

Several meta-analyses have been performed comparing the use of a variety of ultrasonic devices in thyroidectomy to conventional procedures. These studies have shown the superiority of ultrasonic devices for mo...

Authors: Hang Cheng, Ireena Soleas, Nicole C. Ferko, Jeffrey W. Clymer and Joseph F. Amaral

The impact of Lithium on thyroid function in Chinese psychiatric population

Lithium was known to cause thyroid dysfunction and most commonly subclinical hypothyroidism (SCH). The aim of this study is to determine the prevalence of Lithium associated thyroid dysfunction and to identify...

Authors: Kwan Yee Queenie Tsui

Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73

Medullary thyroid cancer (MTC) is a C-cell neoplasm. Surgery remains its main treatment. Promising therapies based on tyrosine kinase inhibitors demand careful patient selection. We previously observed that tw...

Authors: Thierry Ragot, Claire Provost, Aurélie Prignon, Régis Cohen, Michel Lepoivre and Sylvie Lausson

The value of thyroperoxidase as a prognostic factor for differentiated thyroid cancer -- a long-term follow-up study

Thyroperoxidase (TPO) is a membrane-bound protein essential for the production of thyroid hormones; because of this, TPO expression may be impaired in selected thyroid diseases. The goal of this study is to an...

Authors: Yurena Caballero, Eudaldo M. López-Tomassetti, Julián Favre, José R. Santana, Juan J. Cabrera and Juan R. Hernández

Circulating thyrotropin receptor messenger ribonucleic acid is not an effective marker in the follow-up of differentiated thyroid carcinoma

Circulating thyrotropin receptor messenger ribonucleic acid (TSHR mRNA) assay has been validated in the follow-up of differentiated thyroid carcinoma (DTC) because of its high sensitivity during thyroid hormon...

Authors: Surasawadee Ausavarat, Jiraporn Sriprapaporn, Busara Satayaban, Wanna Thongnoppakhun, Aunchalee Laipiriyakun, Boontham Amornkitticharoen, Rujaporn Chanachai and Chaveevan Pattanachak

The ratio of serum free triiodothyronine to free thyroxine in children: a retrospective database survey of healthy short individuals and patients with severe thyroid hypoplasia or central hypothyroidism

The ratio of serum free triiodothyronine (FT3) to free thyroxine (FT4) has been shown to be constant in healthy adults. However, this ratio has been found to be decreased in athyreotic adult patients on levoth...

Authors: Yuji Oto, Koji Muroya, Junko Hanakawa, Yumi Asakura and Masanori Adachi

Thyroid hormones and functional outcomes after ischemic stroke

Stroke is the fifth leading cause of death and the primary cause of long-term adult disability in the United States. Increasing evidence suggests that low T3 levels immediately following acute ischemic stroke ...

Authors: Lena M. O’Keefe, Sarah E. Conway, Alexandra Czap, Carl D. Malchoff, Sharon Benashski, Gilbert Fortunato, Ilene Staff and Louise D. McCullough