Articles

Alginate-based 3D cell culture technique to evaluate the half-maximal inhibitory concentration: an in vitro model of anticancer drug study for anaplastic thyroid carcinoma

Three-dimensional (3D) cell culture methods are identified for simulating the biological microenvironment and demonstrating more similarity to in vivo circumstances. Anaplastic thyroid carcinoma (ATC) is a let...

Authors: Hilda Samimi, Alireza Naderi Sohi, Shiva Irani, Ehsan Arefian, Mojdeh Mahdiannasser, Parviz Fallah and Vahid Haghpanah

Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis

Hashimoto thyroiditis (HT) is the most common inflammatory autoimmune thyroid disease and also the most common cause of hypothyroidism in developed countries. There is evidence of the role of HT in developing ...

Authors: Pouya Abbasgholizadeh, Amirreza Naseri, Ehsan Nasiri and Vahideh Sadra

Nutritional iodine status and obesity

Iodine is an essential component of the thyroid hormones, thyroxine and triiodothyronine. Its availability strictly depends on iodine content of foods, which may vary from very low to very high. Inadequate iod...

Authors: Mariacarla Moleti, Maria Di Mauro, Giuseppe Paola, Antonella Olivieri and Francesco Vermiglio

Poorly differentiated thyroid carcinoma arising from a lithium-induced goiter in a patient with schizophrenia: a case report

Lithium use causes goiter by increasing serum thyroid-stimulating hormone levels through the inhibition of thyroid hormone release. However, there are no reports of poorly differentiated thyroid carcinoma resu...

Authors: Jung Ho Choi, Young Ok Hong, Hyo-Jeong Kim and Ah Ra Jung

Undetectable thyroglobulin makes ¹²³I whole-body scan and stimulated thyroglobulin obsolete in follow-up care of differentiated thyroid cancer: a retrospective study

Differentiated thyroid cancer (DTC) is a common malignancy with increasing incidence. Follow-up care for DTC includes thyroglobulin (Tg) measurement and ultrasound (US) of the neck, combined with ¹³¹I remnant abl...

Authors: Bastiaan Sol, Bert Bravenboer, Brigitte Velkeniers, Steven Raeymaeckers, Marleen Keyaerts and Corina Emilia Andreescu

The relationship between thyroid function and ovarian reserve: a prospective cross-sectional study

Thyroid dysfunction can affect fertility and miscarriage risk by affecting the process of follicular growth, embryo development, implantation, and placental formation. It has been suggested that thyroid disord...

Authors: Roya Kabodmehri, Seyedeh Hajar Sharami, Ziba Zahiri Sorouri, Nasrin Ghanami Gashti, Forozan Milani, Zeinab Chaypaz and Maryam Ghalandari

Association between thyroid disorders and COVID-19: a protocol for a systematic review and meta-analysis

The novel coronavirus (COVID-19) epidemic initially appeared in Wuhan, Hubei Province, China, on 31 December 2019 and was spread rapidly worldwide. Most underlying diseases reported with COVID-19 patients are ...

Authors: Soraya Doustmohammadian, Azam Doustmohammadian and Marjan Momeni

Recurrence of carcinoma showing thymus-like differentiation (CASTLE) involving the thyroid gland

Carcinoma showing thymus-like differentiation (CASTLE) in the thyroid gland is a rare disease with generally a favorable prognosis. Treatment with surgery and adjuvant radiotherapy has been shown to improve lo...

Authors: N. V. Dang, L. X. Son, N. T. T. Hong, N. T. T. Nhung, N. T. Tung and L. V. Quang

Development of metastatic poorly differentiated thyroid cancer from a sub-centimeter papillary thyroid carcinoma in a young patient with a germline MET mutation – association or random chance?

Thyroid cancer dedifferentiation is an unusual observation among young patients and is poorly understood, although a recent correlation to DICER1 gene mutations has been proposed.

Authors: Klara Johansson, Adam Stenman, Johan O. Paulsson, Na Wang, Catharina Ihre-Lundgren, Jan Zedenius and C. Christofer Juhlin

How to use thionamide anti-thyroid drug in the young– what’s new?

The excess thyroid hormone secretion that characterises Graves’ disease (GD) is generated when stimulatory antibodies bind to the thyroid stimulating hormone receptor on the follicular cell of the thyroid gland.

Authors: Tim Cheetham

Falsely diagnosed thyrotoxicosis caused by anti-streptavidin antibodies and pre-wash procedures

Anti-streptavidin antibodies are causal determinants of analytical interference during Thyroid function tests, and numerous reports have detailed such interference, with anti-streptavidin antibodies attracting...

Authors: Takuya Ishikawa, Hiroyuki Sakai, Tokutaro Itaya, Suwanai Hirotsugu, Jumpei Shikuma, Takashi Miwa, Ryo Suzuki and Masato Odawara

Advanced thyroid carcinomas: neural network analysis of ultrasonographic characteristics

Ultrasound is the first-line imaging modality for detection and classification of thyroid nodules. Certain characteristics observable by ultrasound have recently been identified that may indicate malignancy. T...

Authors: Michael Cordes, Theresa Ida Götz, Elmar Wolfgang Lang, Stephan Coerper, Torsten Kuwert and Christian Schmidkonz

Papillary thyroid microcarcinoma with lung metastases: a case report and review of the literature

Distant metastasis from papillary thyroid microcarcinoma (PTMC) is rare. Here we report a case of PTMC with multiple lung metastases.

Authors: Tadafumi Shimizu, Takaaki Oba, Tatsunori Chino, Ai Soma, Mayu Ono, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno, Yoshinori Sato, Takeshi Uehara and Ken-ichi Ito

Associations between maternal urinary iodine assessment, dietary iodine intakes and neurodevelopmental outcomes in the child: a systematic review

Mild to moderate iodine deficiency during pregnancy has been associated with adverse neurodevelopmental outcomes in offspring. Few research studies to date combine assessment of urinary iodine (UIC and/or ICr)...

Authors: Anna M. Monaghan, Maria S. Mulhern, Emeir M. McSorley, J. J. Strain, Matthew Dyer, Edwin van Wijngaarden and Alison J. Yeates

Determination of calcium and parathyroid hormone levels following hemithyroidectomy

Hypocalcemia is one of the main complications of thyroid surgery. We hypothesized that hemithyroidectomy may have an impact on serum parathyroid hormone (PTH) and calcium levels despite only one thyroid lobe i...

Authors: Isabel Fernández Palop, Cristina Fernández Martínez, María Jesús Segura Giménez, M. Carmen Azorin Samper and Rafael García Fuster

The interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review

Pregnancy induces physiological changes that affect the risk of thrombosis and thyroid disease. In this hypothesis-generating review, the physiological changes in the coagulation system and in thyroid function...

Authors: Stine Linding Andersen, Kasper Krogh Nielsen and Søren Risom Kristensen

Risk factors for transient and permanent congenital hypothyroidism: a population-based case-control study

Congenital hypothyroidism (CH) is the most important cause of mental and physical retardation in newborns. The prevalence of CH has been reported high in East Azerbaijan province of Iran. However, the risk fac...

Authors: Fariba Abbasi, Leila Janani, Malihe Talebi, Hosein Azizi, Lotfali Hagiri and Shahnaz Rimaz

Thyroid hemiagenesis with a TI-RADS 2 nodule in the contralateral lobe

Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of the thyroid gland fails to develop. There is an increased incidence of associated thyroid disorders in patients with thyroid hemiagenesis.

Authors: Senai Goitom Sereke, Anthony Oriekot and Felix Bongomin

A case of thyrotoxicosis-induced anemia in a patient with painless thyroiditis

There have been several reports of secondary anemia associated with Graves’ disease. There are no reports of secondary anemia resulting from thyrotoxicosis due to painless thyroiditis (silent thyroiditis). We ...

Authors: Ichiro Komiya, Takeaki Tomoyose, Noriharu Yagi, Gen Ouchi and Tamio Wakugami

Clinical outcome of patients with differentiated thyroid cancer and raised antithyroglobulin antibody levels: a retrospective study

Thyroglobulin (Tg) is a specific tumor marker for differentiated thyroid cancer (DTC). However, in the presence of an antithyroglobulin antibody (TgAb), it becomes unreliable. The purpose of the study was to a...

Authors: Manish Ora, Aftab Hasan Nazar, Prabhakar Mishra, Sukanta Barai, Amitabh Arya, Prasanta Kumar Pradhan and Sanjay Gambhir

Prevalence of thyroid carcinoma in nodules with thy 3 cytology: the role of preoperative ultrasonography and strain elastography

Fine needle aspiration (FNA) cytology, the gold standard in assessing thyroid nodules, is limited by its inability to determine the true risk of malignancy in Thy 3 nodules. Most patients with Thy3 cytology un...

Authors: Giorgos Pikis, Eleni Kandaraki, Demetris Lamnisos, Sereen Abbara, Katerina Kyriakou, Aliki Economides and Panayiotis A. Economides

Association between thyroid autoimmunity and ovarian reserve in women with hypothyroidism

The ovarian function and therefore the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto’s thyroiditis (HT) is the most common in women of reproductive age. Furt...

Authors: Felipe A. Morales-Martínez, Luis H. Sordia-Hernández, Martha Merino Ruiz, Selene Garcia-Luna, Otto H. Valdés-Martínez and Oscar Vidal-Gutierez

Practice patterns and outcomes in the management of Thai patients with Graves’ disease

The treatment of hyperthyroid Graves’ disease (GD) varies considerably among geographic areas. In this study, we aimed to evaluate practice patterns and treatment outcomes in Thai patients with hyperthyroid GD.

Authors: Yotsapon Thewjitcharoen, Krittadhee Karndumri, Waralee Chatchomchuan, Sriurai Porramatikul, Sirinate Krittiyawong, Ekgaluck Wanathayanoroj, Nampetch Lekpittaya, Worawit Kittipoom, Tawee Anuntakulnatee, Somboon Vongterapak, Siriwan Butadej, Soontaree Nakasatien, Rajata Rajatanavin and Thep Himathongkam

Pretibial myxedema in a euthyroid patient: a case report

Pretibial myxedema also known as localized myxedema, thyroid dermopathy, or infiltrative dermopathy and rarely as localized mucinosis is an infrequent manifestation of Graves’ disease. It can appear before, du...

Authors: Rediet Ambachew, Tizita Yosef, Aklilu M. Gebremariam, Lishan Demere, Theodros Aberra, Getahun Tarekegn and Ahmed Reja

Malignancy risk of hyperfunctioning thyroid nodules compared with non-toxic nodules: systematic review and a meta-analysis

Hyperfunctioning or hot nodules are thought to be rarely malignant. As such, current guidelines recommend that hot nodules be excluded from further malignancy risk stratification. The objective of this systema...

Authors: Lorraine W. Lau, Sana Ghaznavi, Alexandra D. Frolkis, Alexandra Stephenson, Helen Lee Robertson, Doreen M. Rabi and Ralf Paschke

Factors affecting thyroid nodule fine needle aspiration non‐diagnostic rates: a retrospective association study of 1975 thyroid biopsies

Thyroid nodules are common in clinical practice, and it is important to distinguish benign nodules, the vast majority, from malignant ones. Non-diagnostic (ND) samples have the potential to delay or mis-diagno...

Authors: Devon Houdek, Sandra Cooke-Hubley, Lakshmi Puttagunta and Donald Morrish

Hyperthyroidism in gestational trophoblastic disease – a literature review

Gestational trophoblastic disease (GTD) is a group of pregnancy-related disorders that arise from abnormal proliferation of placental trophoblast. Some patients with GTD develop hyperthyroidism, a rare but pot...

Authors: Jarett Vanz-Brian Pereira and Taylor Lim

Recent advances in the management of anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC) is undoubtedly the thyroid cancer histotype with the poorest prognosis. The conventional treatment includes surgery, radiotherapy, and conventional chemotherapy. Surgery should ...

Authors: Simone De Leo, Matteo Trevisan and Laura Fugazzola

Selenium and at-risk pregnancy: challenges and controversies

Selenium (Se), an essential trace element, is inserted as selenocysteine into an array of functional proteins and forms the core of various enzymes that play a cardinal role in antioxidant defense mechanisms, ...

Authors: Leonidas H. Duntas

Can we safely reduce the administration of 131-iodine in patients with differentiated thyroid cancer? – experience of the Brugmann hospital in Brussels

131-iodine (¹³¹I) administration after surgery remains a standard practice in differentiated thyroid cancer (DTC). In 2014, the American Thyroid Association presented new guidelines for the staging and management...

Authors: Laura Iconaru, Felicia Baleanu, Georgiana Taujan, Ruth Duttmann, Linda Spinato, Rafik Karmali, Pierre Bergmann and Anne-Sophie Hambye

Total T4 rise in pregnancy: a relook?

Total T4 (TT4) measurement is preferred to free T4 (FT4) especially in last part of pregnancy. Guidelines by American Thyroid Association, European Thyroid Association and Endocrine Society state that TT4 incr...

Authors: Subhodip Pramanik, Pradip Mukhopadhyay and Sujoy Ghosh

Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate

Our previous kinetic analyses of changes in the tumor volume (TV) of papillary thyroid microcarcinomas during active surveillance revealed that the tumors’ growth varied over time from rather rapid growth to s...

Authors: Minoru Kihara, Akira Miyauchi, Hiroo Masuoka, Takuya Higashiyama, Yasuhiro Ito and Akihiro Miya

Teprotumumab: a disease modifying treatment for graves’ orbitopathy

On 21st January 2020, the FDA approved Tepezza (teprotumumab-trbw) for the treatment of active Graves’ orbitopathy (GO) in adults. This approval was based on positive results from two multinational randomised ...

Authors: Michelle Ting and Daniel G. Ezra

Antithyroid drugs and birth defects

Antithyroid drugs (ATDs) are preferred for the treatment of hyperthyroidism caused by Graves’ disease in pregnant women. The drugs have been a recognized treatment for decades, and a general risk of side effec...

Authors: Stine Linding Andersen and Stig Andersen

Macrofollicular variant of papillary thyroid carcinoma with metastasis to femur

Macrofollicular variant of papillary thyroid carcinoma (MFV-PTC) is a rare subtype with histological features and an indolent clinical course that can be confused with nodular goiter or follicular adenoma. How...

Authors: Fernando Candanedo-Gonzalez, Diana Rodriguez-Orihuela and Julian Arista-Nasr

Elevated serum TSH concentrations are associated with higher BMI Z-scores in southern Iranian children and adolescents

Subclinical hypothyroidism is defined as elevated TSH levels while T4 or FT4 levels are normal. Elevated TSH levels are linked with obesity in adults. In a recent meta-analysis in Iran, 6.1% of children below ...

Authors: Ashkan Habib, Mohadeseh Molayemat and Asadollah Habib

Thyroid cancer among patients with thyroid nodules in Yemen: a three-year retrospective study in a tertiary center and a specialty clinic

The prevalence of thyroid cancer is increasing worldwide. No previous data are available on the prevalence of thyroid cancer in Yemen. We performed this study to determine the prevalence of thyroid cancer amon...

Authors: Butheinah A. Al-Sharafi, Jamila A. AlSanabani, Ibraheem M. Alboany and Amani M. Shamsher

Nice guideline on thyroid disease: where does it take us with liothyronine?

The new NICE guidelines on thyroid disease and its management do not recommend the routine use of liothyronine, but do not completely rule it out either. Guidelines from the British and European Thyroid Associ...

Authors: Graham P. Leese

The effectiveness of cognitive- behavioral therapy on quality of life in women with hypothyroidism in the reproductive age: a randomized controlled trial

Worldwide, hypothyroidism affects 3.7% of the population, and is associated with impaired quality of life. This study aimed to evaluate the effect of cognitive- behavioral therapy (CBT) on the quality of life ...

Authors: Sohaila Rezaei, Parvin Abedi, Elham Maraghi, Najmeh Hamid and Homaira Rashidi

Adequate timing and constant supervision are the keys for successful implementation of levothyroxine or levothyroxine/paracetamol absorption test

Levothyroxine (LT₄) pseudomalabsorption due to medication non-adherence results in significant costs for Health Service. High dose LT₄ or LT₄/paracetamol absorption test is used in such cases. Hence, establishmen...

Authors: Krzysztof C. Lewandowski, Katarzyna Dąbrowska, Magdalena Basińska-Lewandowska, Marek Bolanowski, Marek Ruchała and Andrzej Lewiński

Time-dependent changes in FT4 and FT3 levels measured using mass spectrometry after an acute ingestion of excess levothyroxine in a case with hypothyroidism

Thyrotoxicosis is common disorder among endocrine dysfunctions. It is not rare that the free thyroid hormone level exceeds the measurement range of immunoassay. Such extreme high concentration of free thyroid ...

Authors: Yuko Ito, Satoru Suzuki, Yoshiko Matsumoto, Chiyo Ohkouchi, Satoshi Suzuki, Manabu Iwadate, Sanae Midorikawa, Susumu Yokoya, Shinichi Suzuki and Hiroki Shimura

Should radioiodine now be first line treatment for Graves’ disease?

Radioiodine represents a cost-effective treatment option for Graves’ disease. In the UK, it is traditionally reserved for patients who relapse after initial thionamide therapy. In a change from current practic...

Authors: Onyebuchi E. Okosieme, Peter N. Taylor and Colin M. Dayan

Falsely undetectable TSH in a euthyroid patient

Measuring thyroid hormone levels is essential and helpful in the diagnosis of thyroid diseases.

Authors: Monireh Rahimkhani, Kiana Kazemian and Rashid Ramezani Daryasari

Cross-sectional and prospective study on anti-Müllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer

Anti-Müllerian hormone (AMH) decreases acutely after post-surgical radioactive iodine (RAI) ablation in females with differentiated thyroid cancer (DTC).

Authors: Miranda Mittica, Andrea Dotto, Martina Comina, Marsida Teliti, Eleonora Monti and Massimo Giusti

Life-threatening complications of high doses of intravenous methylprednisolone for treatment of Graves’ orbitopathy

Treatment of moderate to severe Graves’ orbitopathy (GO) is based mainly on intravenous pulses of methylprednisolone. High doses of methylprednisolone can exert several adverse effects, some of which might be ...

Authors: Dorota Walasik-Szemplińska, Grzegorz Kamiński and Iwona Sudoł-Szopińska

Pre-sternal thyroid swellings: a case of rare aberrant site recurrence and review of literature

Thyroid swellings enlarge caudally into the mediastinum behind the sternum. Pre-sternal swelling of thyroid origin is very rare. We present our case of pre-sternal thyroid swelling which was albeit a surprisin...

Authors: Lovenish Bains, Sushant Bhatia, Rohit Kaushik, Sudhir Kumar Jain, Chandra Bhushan Singh, Shramana Mandal and Daljit Kaur

Meeting Abstracts from the 67^th Annual British Thyroid Association Meeting

Authors:

The surgical management of locally advanced well-differentiated thyroid carcinoma: changes over the years according to the AJCC 8th edition Cancer Staging Manual

Well-differentiated thyroid carcinoma is defined as locally advanced in the presence of an extra thyroid extension, e.g., when the surrounding structures such as the trachea, larynx, esophagus and main blood v...

Authors: Alessio Metere, Valerio Aceti and Laura Giacomelli

Association of thyroid hormones with resting energy expenditure and complement C3 in normal weight high body fat women

A high body fat percentage has a specific effect on activation of the hypothalamic-pituitary-thyroid axis. On the other hand, a slight change in thyroid hormones can affect metabolism and body composition as w...

Authors: Maryam Karkhaneh, Mostafa Qorbani, Asal Ataie-Jafari, Mohamad Reza Mohajeri-Tehrani, Hamid Asayesh and Saeed Hosseini

Painless destructive thyroiditis in a patient with resistance to thyroid hormone: a case report

Resistance to thyroid hormone (RTH) usually features a syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH) without suppression of the typical high thyroid hormone levels. However, some p...

Authors: Tomoko Nagamine, Jaeduk Yoshimura Noh, Naoya Emoto, Takahito Kogai, Akira Hishinuma, Fumitaka Okajima and Hitoshi Sugihara